Department of Physical Medicine and Rehabilitation, Tavşanlı Doç. Dr. Mustafa Kalemli Hospital, Kütahya, Turkey.
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
Pain Manag Nurs. 2023 Feb;24(1):60-67. doi: 10.1016/j.pmn.2022.07.010. Epub 2022 Sep 1.
Fibromyalgia syndrome (FMS) is a chronic pain condition that requires multidisciplinary treatment. Vitamin K is an antioxidant that plays a role in many reactions in the body, and its effectiveness in FMS has not been studied before.
We aimed to evaluate vitamin K levels in FMS patients and their relationship with pain, disease activity, quality of life, and inflammatory cytokines.
Eighty-eight female patients with FMS and 87 controls were included in the study. Vitamin K and inflammatory cytokine (interleukin-6 [IL-6], IL-8, tumor necrosis factor [TNF]-alfa) serum levels were measured in both groups. Visual Analog Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), and Short Form-36 (SF-36) scales were used.
No statistically significant differences in vitamin K levels between the two groups, and no relationships were found between these levels and pain, FIQ, SF-36, and inflammatory cytokines (p > .05). While IL-6 and TNF-alpha levels were found to be high in the FMS group compared with the control group (p < .05), no difference in IL-8 levels was noted (p > .05). In the FMS group, positive correlations were found between IL-6 and FIQ, and between TNF-alpha and physical role difficulty(p > .05).
Overall, the results of this study do not provide any evidence of an association between FMS and vitamin K levels. However, high IL-6 and TNF-alpha levels suggest that low-intensity inflammation may accompany FMS and have a negative impact on physical activity. Future studies are needed to determine the relationship between vitamin K and FMS.
纤维肌痛综合征（FMS）是一种慢性疼痛疾病，需要多学科治疗。维生素 K 是一种抗氧化剂，在体内的许多反应中发挥作用，其在 FMS 中的疗效尚未得到研究。
我们旨在评估 FMS 患者的维生素 K 水平及其与疼痛、疾病活动度、生活质量和炎症细胞因子的关系。
本研究纳入了 88 名女性 FMS 患者和 87 名对照组。测量了两组患者的维生素 K 和炎症细胞因子（白细胞介素-6 [IL-6]、IL-8、肿瘤坏死因子-α [TNF-α]）的血清水平。使用视觉模拟量表（VAS）、纤维肌痛影响问卷（FIQ）和简明健康状况量表 36 项（SF-36）进行评估。
两组间维生素 K 水平无统计学差异，且这些水平与疼痛、FIQ、SF-36 和炎症细胞因子之间无相关性（p >.05）。与对照组相比，FMS 组的 IL-6 和 TNF-α 水平较高（p <.05），而 IL-8 水平无差异（p >.05）。在 FMS 组中，IL-6 与 FIQ 之间以及 TNF-α 与身体角色困难之间存在正相关（p >.05）。
总的来说，本研究结果并未提供 FMS 与维生素 K 水平之间存在关联的任何证据。然而，高 IL-6 和 TNF-α 水平表明低强度炎症可能伴随着 FMS，并对身体活动产生负面影响。需要进一步研究来确定维生素 K 与 FMS 之间的关系。
