循环血浆半乳糖凝集素-3可预测急性心肌梗死后住院期间新发心房颤动。
Circulating plasma galectin-3 predicts new-onset atrial fibrillation in patients after acute myocardial infarction during hospitalization.
机构信息
Heart Center and Beijing Key Laboratory of Hypertension, Department of Cardiology, Chaoyang Hospital, Capital Medical University, 8th Gongtinanlu Rd, Chaoyang District, Beijing, 100020, China.
Emergency Department, Third Clinical Medical College, Peking University, Beijing, 100191, China.
出版信息
BMC Cardiovasc Disord. 2022 Sep 3;22(1):392. doi: 10.1186/s12872-022-02827-y.
BACKGROUND
New-onset atrial fibrillation (NOAF) is a common complication in patients with acute myocardial infarction (AMI) during hospitalization. Galectin-3 (Gal-3) is a novel inflammation marker that is significantly associated with AF. The association between post-AMI NOAF and Gal-3 during hospitalization is yet unclear.
OBJECTIVE
The present study aimed to investigate the predictive value of plasma Gal-3 for post-AMI NOAF.
METHODS
A total of 217 consecutive patients admitted with AMI were included in this retrospective study. Peripheral venous blood samples were obtained within 24 h after admission and plasma Gal-3 concentrations were measured.
RESULTS
Post-AMI NOAF occurred in 18 patients in this study. Patients with NOAF were older (p < 0.001) than those without. A higher level of the peak brain natriuretic peptide (BNP) (p < 0.001) and Gal-3 (p < 0.001) and a lower low-density lipoprotein cholesterol level (LDL-C) (p = 0.030), and an estimated glomerular filtration rate (e-GFR) (p = 0.030) were recorded in patients with post-AMI NOAF. Echocardiographic information revealed that patients with NOAF had a significantly decreased left ventricular eject fraction (LVEF) (p < 0.001) and an increased left atrial diameter (LAD) (p = 0.004) than those without NOAF. The receiver operating characteristic (ROC) curve analysis revealed a significantly higher value of plasma Gal-3 in the diagnosis of NOAF for patients with AMI during hospitalization (area under the curve (p < 0.001), with a sensitivity of 72.22% and a specificity of 72.22%, respectively. Multivariate logistic regression model analysis indicated that age (p = 0.045), plasma Gal-3 (p = 0.018), and LAD (p = 0.014) were independent predictors of post-MI NOAF.
CONCLUSIONS
Plasma Gal-3 concentration is an independent predictor of post-MI NOAF.
背景
新发心房颤动（NOAF）是住院期间急性心肌梗死（AMI）患者的常见并发症。半乳糖凝集素-3（Gal-3）是一种新型炎症标志物，与 AF 显著相关。AMI 后住院期间发生的 NOAF 与 Gal-3 之间的关系尚不清楚。
目的
本研究旨在探讨血浆 Gal-3 对 AMI 后 NOAF 的预测价值。
方法
本回顾性研究共纳入 217 例连续入院的 AMI 患者。入院后 24 小时内采集外周静脉血样，测量血浆 Gal-3 浓度。
结果
本研究中有 18 例患者发生 AMI 后 NOAF。NOAF 组患者年龄大于无 NOAF 组（p<0.001）。NOAF 组患者的峰值脑钠肽（BNP）（p<0.001）和 Gal-3（p<0.001）水平较高，低密度脂蛋白胆固醇（LDL-C）（p=0.030）和估算肾小球滤过率（e-GFR）（p=0.030）水平较低。超声心动图信息显示，NOAF 组患者的左心室射血分数（LVEF）明显降低（p<0.001），左心房内径（LAD）增大（p=0.004）。受试者工作特征（ROC）曲线分析显示，住院期间 AMI 患者的血浆 Gal-3 值对诊断 NOAF 具有更高的价值（曲线下面积（p<0.001），其灵敏度为 72.22%，特异性为 72.22%。多变量 logistic 回归模型分析表明，年龄（p=0.045）、血浆 Gal-3（p=0.018）和 LAD（p=0.014）是 AMI 后发生 NOAF 的独立预测因素。
结论
血浆 Gal-3 浓度是 AMI 后发生 NOAF 的独立预测因素。
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