高尿酸血症患者尿前列腺素与尿酸的关系。

The association of urinary prostaglandins with uric acid in hyperuricemia patients.

机构信息

Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, P.R. China.

Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, P.R. China.

出版信息

BMC Nephrol. 2022 Sep 3;23(1):302. doi: 10.1186/s12882-022-02928-y.

DOI:10.1186/s12882-022-02928-y

PMID:36057582

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9441060/

Abstract

PURPOSE

To explore the association between uric acid and urinary prostaglandins in male patients with hyperuricemia.

METHODS

A total of 38 male patients with hyperuricemia in outpatients of Huadong Hospital from July 2018 to January 2020 were recruited. Serum uric acid (SUA), 24 h urinary uric acid excretion and other indicators were detected respectively. 10 ml urine was taken to determine prostaglandin prostaglandin D (PGD), prostaglandin E1 (PGE1), prostaglandin E2 (PGE2), 6-keto-PGF1α, thromboxane A2 (TXA2) and thromboxane B2 (TXB2). Fraction of uric acid excretion (FEua) and uric acid clearance rate (Cua) were calculated. According to the mean value of FEua and Cua, patients were divided into two groups, respectively. The independent-samples t test and the Mann-Whitney U test were applied for normally and non-normally distributed data, respectively.

RESULTS

After adjusting confounding factors (age, BMI, eGFR, TG, TC, HDL and LDL), SUA was negatively correlated with urinary PGE1(r = -0.615, P = 0.009) and PGE2(r = -0.824, P < 0.001). Compared with SUA1 group (SUA < 482.6 mg/dl), SUA2 (SUA [Formula: see text] 482.6 mg/dl) had lower urinary PGE1(P = 0.022) and PGE2(P = 0.019) levels. Cua was positively correlated with PGE2 (r = 0.436, P = 0.01). The correlation persisted after adjustment for age, BMI, eGFR, TG, TC, HDL and LDL by multiple linear regression analysis. In the Cua1 group (Cua < 4.869 mL /min/1.73 m), PGE2 were lower than that in Cua2 (Cua [Formula: see text] 4.869 mL /min/1.73 m) group (P = 0.011).

CONCLUSIONS

In male patients with hyperuricemia, SUA was negatively correlated with urinary PGE2, Cua was positively correlated with urinary PGE2. Urinary PGE2 were significantly different between different SUA and Cua groups.

摘要

目的

探讨男性高尿酸血症患者尿酸与尿前列腺素的关系。

方法

2018 年 7 月至 2020 年 1 月，选取华东医院门诊 38 例男性高尿酸血症患者，分别检测血清尿酸（SUA）、24 h 尿尿酸排泄等指标。留取 10 ml 尿液，测定前列腺素 D（PGD）、前列腺素 E1（PGE1）、前列腺素 E2（PGE2）、6-酮前列腺素 F1α、血栓烷 A2（TXA2）和血栓烷 B2（TXB2）。计算尿酸排泄分数（FEua）和尿酸清除率（Cua）。根据 FEua 和 Cua 的平均值将患者分为两组，分别应用独立样本 t 检验和 Mann-Whitney U 检验进行正态和非正态分布数据的检验。

结果

调整混杂因素（年龄、BMI、eGFR、TG、TC、HDL 和 LDL）后，SUA 与尿 PGE1（r=-0.615，P=0.009）和 PGE2（r=-0.824，P<0.001）呈负相关。与 SUA1 组（SUA<482.6 mg/dl）相比，SUA2 组（SUA[Formula: see text]482.6 mg/dl）的尿 PGE1（P=0.022）和 PGE2（P=0.019）水平较低。Cua 与 PGE2 呈正相关（r=0.436，P=0.01）。通过多元线性回归分析调整年龄、BMI、eGFR、TG、TC、HDL 和 LDL 后，相关性仍然存在。在 Cua1 组（Cua<4.869 mL/min/1.73 m），PGE2 低于 Cua2 组（Cua[Formula: see text]4.869 mL/min/1.73 m）（P=0.011）。