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尿钠排泄与尿酸的关系及其对中国年轻成年人高血压前期发病风险的交互作用。

Association between urinary sodium excretion and uric acid, and its interaction on the risk of prehypertension among Chinese young adults.

机构信息

Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi'an, China.

出版信息

Sci Rep. 2018 May 17;8(1):7749. doi: 10.1038/s41598-018-26148-3.

DOI:10.1038/s41598-018-26148-3
PMID:29773847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5958063/
Abstract

High uric acid (UA) level and high salt intake are reportedly associated with cardiovascular disease. This study investigated the association between UA and urinary sodium excretion, as well as its interaction on the risk of prehypertension. A total of 1869 participants without hypertension were recruited from a previously established cohort in Shaanxi Province, China. The participants were classified as normotensive or prehypertensive on the basis of their blood pressure. Increasing quartiles of sodium excretion were associated with high urinary UA/creatinine levels in prehypertensive participants. Estimated sodium excretion positively correlated with urinary UA/creatinine excretions in the prehypertensive group. In addition, the multivariate-adjusted odds ratios for prehypertension compared with normotension were 1.68 (1.27-2.22) for sodium excretion and 1.71 (1.21-2.42) for serum UA. Increasing sodium excretion and serum UA were associated with higher risk of prehypertension. Compared with the lowest quartiles, the highest sodium excretion and serum UA quartiles entailed 3.48 times greater risk of prehypertension. Sodium excretion is associated with urinary UA excretion in prehypertensive participants. The present study shows that high levels of salt intake and serum UA simultaneously are associated with a higher risk of prehypertension.

摘要

高尿酸（UA）水平和高盐摄入量据称与心血管疾病有关。本研究调查了 UA 与尿钠排泄之间的关系，以及它们对高血压前期风险的相互作用。共有 1869 名无高血压的参与者从中国陕西省之前建立的队列中招募。根据血压将参与者分为血压正常或高血压前期。尿 UA/肌酐水平随尿钠排泄量的增加而升高。在高血压前期组中，估计的钠排泄量与尿 UA/肌酐排泄量呈正相关。此外，与血压正常相比，尿钠排泄和血清 UA 升高的高血压前期的多变量调整比值比分别为 1.68（1.27-2.22）和 1.71（1.21-2.42）。尿钠排泄和血清 UA 升高与高血压前期风险增加相关。与最低四分位数相比，尿钠排泄和血清 UA 最高四分位数的高血压前期风险高 3.48 倍。尿钠排泄与高血压前期参与者的尿 UA 排泄有关。本研究表明，高盐摄入量和血清 UA 水平同时升高与高血压前期风险增加有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f00/5958063/0b77d5e670b5/41598_2018_26148_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f00/5958063/c08f3115b2a7/41598_2018_26148_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f00/5958063/75b4e3594a18/41598_2018_26148_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f00/5958063/0b77d5e670b5/41598_2018_26148_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f00/5958063/c08f3115b2a7/41598_2018_26148_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f00/5958063/75b4e3594a18/41598_2018_26148_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f00/5958063/0b77d5e670b5/41598_2018_26148_Fig3_HTML.jpg

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