Clarke P S
Ann Allergy. 1987 Jul;59(1):25-8.
The paper describes a simple clinical method of performing allergic nasal challenges. It was found to give no complications in over 1,000 challenges with D. pteronyssinus solution. It requires no special apparatus. Reasons for not measuring nasal airways resistance are given. In 1,167 challenges, positive nasal challenges agreed with positive skin prick tests 943 times (81%). Twenty-five positive nasal tests had negative skin tests (2%). One hundred and ninety-nine negative nasal tests had positive skin tests (17%). In 60 patients who had positive RAST (Fadel-Nalebuff modification), 14 (23%) nasal challenges were negative. Five positive nasal challenges had negative RASTS (8%). This is the largest series of mite nasal challenges correlated to skin and RAST tests that has been published.
本文描述了一种进行变应性鼻激发试验的简单临床方法。在使用粉尘螨溶液进行的1000多次激发试验中，未发现该方法有任何并发症。它不需要特殊设备。文中给出了不测量鼻气道阻力的原因。在1167次激发试验中，鼻激发试验阳性与皮肤点刺试验阳性相符943次（81%）。25次鼻激发试验阳性但皮肤试验阴性（2%）。199次鼻激发试验阴性但皮肤试验阳性（17%）。在60例RAST（法德尔-纳勒布夫改良法）阳性的患者中，14例（23%）鼻激发试验阴性。5次鼻激发试验阳性但RAST试验阴性（8%）。这是已发表的与皮肤试验和RAST试验相关的最大规模的螨鼻激发试验系列。
