Wetmore L A, Derksen F J, Blaze C A, Eyster G E
Am J Vet Res. 1987 Jun;48(6):971-6.
The relationship between mixed venous O2 tension and cardiac output was studied in six anesthetized horses breathing 100% O2. Cardiac output, O2 consumption, mean arterial pressure, heart rate, and arterial and venous blood gases were measured after administration of xylazine or dobutamine to horses in lateral, sternal, and dorsal recumbencies. After approximately 3 hours, Escherichia coli endotoxin was administered while horses were in dorsal recumbency, and all measurements were repeated. Relationships between cardiac index (CI) and PVO2, heart rate, mean arterial pressure, jugular PVO2, and PVO2 of blood from a superficial limb vein were evaluated by linear regression analysis. Mean arterial pressure was significantly (P less than 0.05) correlated with CI in horses in all positions and after endotoxin administration. However, data points were poorly grouped. Heart rate and CI were significantly correlated in horses in all positions, but not after endotoxin administration. Correlations between jugular PVO2 and PVO2 of blood from a superficial limb vein were not significant in horses in sternal recumbency, and PVO2 of blood from a superficial limb vein was not significantly correlated with CI in horses in lateral recumbency. There was a significant and tight correlation between PVO2 and CI in horses in all positions and after endotoxin administration.
在六匹吸入100%氧气的麻醉马中研究了混合静脉血氧分压与心输出量之间的关系。在给处于侧卧、胸骨卧和背卧姿势的马注射赛拉嗪或多巴酚丁胺后，测量心输出量、氧消耗、平均动脉压、心率以及动脉和静脉血气。大约3小时后，在马处于背卧姿势时给予大肠杆菌内毒素，并重复所有测量。通过线性回归分析评估心脏指数（CI）与混合静脉血氧分压（PVO2）、心率、平均动脉压、颈静脉PVO2以及浅表肢体静脉血的PVO2之间的关系。在所有姿势的马以及给予内毒素后，平均动脉压与CI显著相关（P小于0.05）。然而，数据点分布不佳。在所有姿势的马中，心率与CI显著相关，但给予内毒素后不相关。在胸骨卧姿势的马中，颈静脉PVO2与浅表肢体静脉血的PVO2之间的相关性不显著，在侧卧姿势的马中，浅表肢体静脉血的PVO2与CI不显著相关。在所有姿势的马以及给予内毒素后，PVO2与CI之间存在显著且紧密的相关性。
