陈皮（Citri Reticulatae Pericarpium）：一种具有多种功效的果皮，可用于治疗心血管疾病。
Citri Reticulatae Pericarpium (Chenpi): A multi-efficacy pericarp in treating cardiovascular diseases.
机构信息
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, 511436 Guangzhou, China.
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, College of Pharmacy, Jinan University, 511436 Guangzhou, China; Department of Critical Care Medicine, Maoming People's Hospital, Maoming, 525000 Guangdong, China.
出版信息
Biomed Pharmacother. 2022 Oct;154:113626. doi: 10.1016/j.biopha.2022.113626. Epub 2022 Sep 1.
Citri Reticulatae Pericarpium (CRP) has been utilized as a versatile medicinal herb with wide cardiovascular benefits in Asian nations for centuries. Accumulating evidence suggests that CRP and its components are effective in preventing cardiovascular diseases (CVDs) such as atherosclerosis, myocardial infarction, myocardial ischemia, arrhythmia, cardiac hypertrophy, heart failure, and hypertension. Studies show that the two most bioactive components of CRP are flavonoids and volatile oils. The cardiovascular protective effects of CRP have attracted considerable research interest due to its hypolipidemic, antiplatelet activity, antioxidant and anti-inflammatory effects. Hereby, we provide a rigorous and up-to-date overview of the cardiovascular protective properties and the potential molecular targets of CRP, and finally highlight the pharmacokinetics and the therapeutic potential of the main pharmacologically active components of CRP to treat CVDs.
枳实（CRP）作为一种多功能的药用草本植物，在亚洲国家已有数百年的广泛心血管益处。越来越多的证据表明，CRP 及其成分在预防心血管疾病（CVDs）方面非常有效，如动脉粥样硬化、心肌梗死、心肌缺血、心律失常、心肌肥厚、心力衰竭和高血压。研究表明，CRP 的两种最具生物活性的成分是类黄酮和挥发油。CRP 的心血管保护作用因其具有降血脂、抗血小板活性、抗氧化和抗炎作用而引起了相当大的研究兴趣。因此，我们对 CRP 的心血管保护特性和潜在的分子靶点进行了严格和最新的综述，并最终强调了 CRP 主要药理活性成分的药代动力学和治疗 CVDs 的治疗潜力。
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