Rowe L D, Corrier D E, Reagor J C, Jones L P
Am J Vet Res. 1987 Jun;48(6):992-7.
The dried, ground aerial portions of the plant Cassia roemeriana were administered to each of seven calves at a dosage of 10 g/kg of body weight/day for 2 to 10.5 days and to each of six goats at a dosage of 10 g/kg/day for 5 days or 5 or 7 g/kg/day for 23 to 25 days. Experimentally induced C roemeriana poisoning in both species resulted in hepatopathic poisoning characterized by a brief survival period (3.9 to 7.9 days), moderate-to-severe hepatocellular damage, and little or no evidence of injury to skeletal muscle or resulted in myopathic poisoning characterized by a longer period of survival, mild-to-severe skeletal myopathy, and mild hepatocellular injury. The minimal dosage that induced hepatopathic poisoning (also the minimal lethal dosage) was 10 g/kg/day for 3 days in calves and for 5 days in goats. The minimal dosage that induced the myopathic syndrome (as determined by the earliest increase in serum creatine kinase activity) was 10 g/kg/day for 6 days for calves and 5 g/kg/day for 10 to 16 days for goats.
将植物罗氏决明干燥、研磨后的地上部分，以10克/千克体重/天的剂量分别喂给7头小牛，持续2至10.5天；以10克/千克/天的剂量喂给6只山羊，持续5天，或以5或7克/千克/天的剂量喂给山羊，持续23至25天。在这两个物种中，实验性诱导的罗氏决明中毒导致了肝病性中毒，其特征为存活期短暂（3.9至7.9天）、中度至重度肝细胞损伤，且骨骼肌损伤很少或没有迹象；或者导致了肌病性中毒，其特征为存活期较长、轻度至重度骨骼肌病变以及轻度肝细胞损伤。在小牛中，诱导肝病性中毒的最小剂量（也是最小致死剂量）为10克/千克/天，持续3天；在山羊中为10克/千克/天，持续5天。诱导肌病综合征（根据血清肌酸激酶活性最早升高来确定）的最小剂量，在小牛中为10克/千克/天，持续6天；在山羊中为5克/千克/天，持续10至16天。
