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Mucus sialylation determines intestinal host-commensal homeostasis.黏蛋白唾液酸化决定肠道共生稳态。
Cell. 2022 Mar 31;185(7):1172-1188.e28. doi: 10.1016/j.cell.2022.02.013. Epub 2022 Mar 17.
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Mucins Dynamics in Physiological and Pathological Conditions.黏液素在生理和病理条件下的动态变化。
Int J Mol Sci. 2021 Dec 20;22(24):13642. doi: 10.3390/ijms222413642.
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Gut microbiota in burned patients with Clostridioides difficile infection.烧伤合并艰难梭菌感染患者的肠道菌群。
Burns. 2022 Aug;48(5):1120-1129. doi: 10.1016/j.burns.2021.11.023. Epub 2021 Dec 1.
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Oroxylin A maintains the colonic mucus barrier to reduce disease susceptibility by reconstituting a dietary fiber-deprived gut microbiota.木犀草素A通过重建缺乏膳食纤维的肠道微生物群来维持结肠黏液屏障,从而降低疾病易感性。
Cancer Lett. 2021 Sep 1;515:73-85. doi: 10.1016/j.canlet.2021.05.018. Epub 2021 May 28.
5
Increased Listeria monocytogenes Dissemination and Altered Population Dynamics in Muc2-Deficient Mice.黏蛋白 2 缺陷型小鼠中李斯特菌的传播增加和种群动态改变。
Infect Immun. 2021 Mar 17;89(4). doi: 10.1128/IAI.00667-20.
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Effects of intestinal trefoil factor on intestinal mucus barrier in burned mice.肠三叶因子对烧伤小鼠肠道黏液屏障的影响。
Am J Transl Res. 2020 Nov 15;12(11):7187-7198. eCollection 2020.
7
Mucin-Degrading Microbes Release Monosaccharides That Chemoattract and Facilitate Colonization of the Human Intestinal Mucus Layer.降解黏蛋白的微生物释放单糖,这些单糖可趋化并促进人类肠道黏液层的定殖。
ACS Infect Dis. 2021 May 14;7(5):1126-1142. doi: 10.1021/acsinfecdis.0c00634. Epub 2020 Nov 11.
8
Trefoil Factor Family (TFF) Peptides and Their Diverse Molecular Functions in Mucus Barrier Protection and More: Changing the Paradigm.三叶因子家族(TFF)肽及其在黏液屏障保护等方面的多样化分子功能:改变范式。
Int J Mol Sci. 2020 Jun 25;21(12):4535. doi: 10.3390/ijms21124535.
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Mechanistic study of PDIA1-catalyzed TFF3 dimerization during sepsis.在脓毒症中 PDIA1 催化 TFF3 二聚化的机制研究。
Life Sci. 2020 Aug 15;255:117841. doi: 10.1016/j.lfs.2020.117841. Epub 2020 May 23.
10
Mucin glycans attenuate the virulence of Pseudomonas aeruginosa in infection.粘蛋白糖链可降低铜绿假单胞菌在感染中的毒力。
Nat Microbiol. 2019 Dec;4(12):2146-2154. doi: 10.1038/s41564-019-0581-8. Epub 2019 Oct 14.

[肠道黏液屏障与烧伤后肠道损伤修复的研究进展]

[Research progress of intestinal mucus barrier and the repair of intestinal damage after burn injury].

作者信息

Wu D, Su S, Wei Y, Peng X

机构信息

Clinical Medical Research Center, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

Clinical Medical Research Center, Institute of Burn Research, State Key Laboratory of Trauma, Burns and Combined Injury, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

出版信息

Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 Aug 20;38(8):788-793. doi: 10.3760/cma.j.cn501225-20220701-00280.

DOI:10.3760/cma.j.cn501225-20220701-00280
PMID:36058702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11705554/
Abstract

The intestinal mucus layer is the first line of innate host defense and provides energy for the growth of the intestinal flora. In addition, it plays an important role in regulating intestinal microecology and maintaining intestinal homeostasis. This paper reviews the synthesis, secretion, processing, and modification of intestinal mucus, and focuses on the effect of intestinal mucus barrier on intestinal injury repair and the regulation of intestinal mucus barrier by special nutrients after burn injury.

摘要

肠道黏液层是宿主先天性防御的第一道防线,为肠道菌群的生长提供能量。此外,它在调节肠道微生态和维持肠道稳态方面发挥着重要作用。本文综述了肠道黏液的合成、分泌、加工和修饰,并重点探讨了肠道黏液屏障对烧伤后肠道损伤修复的影响以及特殊营养物质对烧伤后肠道黏液屏障的调节作用。