Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510055, China.
Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Hunan Key Laboratory of Oral Health Research, Changsha, Hunan, China.
BMC Oral Health. 2022 Sep 4;22(1):374. doi: 10.1186/s12903-022-02412-x.
Regenerative endodontic procedures (REPs) have achieved clinical success on the immature permanent teeth with pulp necrosis, and can promote root development. However, preoperative factors and their effects on root development of REPs have not been definitely concluded. The aim of this study was to investigate the preoperative factors that may influence the root development of REPs.
A total of 116 teeth in 110 patients treated with REPs in the Paediatric Dentistry Department and Endodontics Department from 2013 to 2017 were included in this study. Preoperative factors including aetiology, age, diagnosis and initial root morphology were collected retrospectively, and the associations between these factors and root development after REPs were analysed by Fisher's exact test and multivariate logistic regression model.
The overall rate of root development after REPs was 89.7%. The dens evaginatus group showed a higher rate (98.8%) in root development than the trauma group (67.6%) (P < 0.01). There was no significant difference among the different age groups (7-13 years old) or among different diagnoses groups (P > 0.05). And it showed in the trauma group that the teeth with apical foramen sizes larger than 3 mm significantly promoted root development than those smaller than 3 mm (P < 0.01). Multivariate logistic regression indicated that aetiology was significantly correlated with root development of REPs (OR: 0.07, 95% CI 0.007, 0.627, P < 0.05).
The REPs promoted more root developments in the dens evaginatus group than the trauma group, indicating that aetiology may be correlated with the root development of REPs.
再生性牙髓治疗（REP）在伴有牙髓坏死的未成熟恒牙中取得了临床成功，并能促进牙根发育。然而，术前因素及其对 REP 牙根发育的影响尚未得到明确结论。本研究旨在探讨可能影响 REP 牙根发育的术前因素。
本研究共纳入 2013 年至 2017 年期间在儿科牙科和牙髓科接受 REP 治疗的 110 名患者的 116 颗牙齿。回顾性收集了术前因素，包括病因、年龄、诊断和初始牙根形态，并通过 Fisher 确切检验和多因素 logistic 回归模型分析这些因素与 REP 后牙根发育的关系。
REP 后牙根发育的总体率为 89.7%。畸形牙尖窝组的牙根发育率（98.8%）高于创伤组（67.6%）（P<0.01）。不同年龄组（7-13 岁）或不同诊断组之间无显著差异（P>0.05）。在创伤组中，根尖孔大小大于 3mm 的牙齿的牙根发育明显优于根尖孔小于 3mm 的牙齿（P<0.01）。多因素 logistic 回归分析表明，病因与 REP 的牙根发育显著相关（OR：0.07，95%CI 0.007，0.627，P<0.05）。
REP 在畸形牙尖窝组中促进了更多的牙根发育，表明病因可能与 REP 的牙根发育有关。
