多发性硬化症（MS）患者中不宁腿综合征（RLS）的患病率：系统评价与荟萃分析——最新进展
The prevalence of restless legs syndrome (RLS) in patients with multiple sclerosis (MS): a systematic review and meta-analysis-an update.
作者信息
Zali Alireza, Motavaf Mahsa, Safari Saeid, Ebrahimi Narges, Ghajarzadeh Mahsa, Khoshnood Reza Jalili, Mirmosayyeb Omid
机构信息
Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Comprehensive Center of Excellence, Shohada-E-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Qods Sq., Building no 1, 4th floor, Tajrish, Tehran, Iran.
School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Neurol Sci. 2023 Jan;44(1):67-82. doi: 10.1007/s10072-022-06364-6. Epub 2022 Sep 5.
INTRODUCTION
The prevalence of restless legs syndrome (RLS) is reported to vary in patients with multiple sclerosis (MS) in studies which are conducted in different populations. The goal of this systematic review and meta-analysis is to update the prevalence of RLS in MS cases.
METHODS
We searched PubMed, Scopus, EMBASE, CINAHL, Web of Science, Google Scholar, and gray literature including references from identified studies and conference abstracts which were published up to June 2021. Data on the total number of participants, first author, country, disease duration, number of controls, mean patient age, male and female numbers, mean EDSS, and number of cases and/or controls with RLS were extracted from the included studies.
RESULTS
The literature search revealed 855 articles; after deleting duplicates, 530 remained. For the meta-analysis, 75 studies were included (Fig. 1). In six articles, the authors did not differentiate between CIS and MS cases when reporting RLS cases. In total, 15,411 MS/CIS patients were evaluated and 4309 had RLS. The pooled prevalence of RLS was 28% (95% CI: 24-33%). The pooled prevalence of RLS in men was 22% (95% CI: 17-26%), and the pooled prevalence of RLS in women was 30% (95% CI: 25-35%). The pooled prevalence of RLS in controls was 8% (95% CI: 6-10%).
CONCLUSION
The results of this systematic review and meta-analysis show that the pooled prevalence of RLS is 28% in MS cases and 8%. The pooled prevalence is higher in women than men (30% vs 22%).
引言
在针对不同人群开展的研究中，据报告，多发性硬化症（MS）患者中不宁腿综合征（RLS）的患病率有所不同。本系统评价和荟萃分析的目的是更新MS病例中RLS的患病率。
方法
我们检索了PubMed、Scopus、EMBASE、CINAHL、Web of Science、谷歌学术以及灰色文献，包括截至2021年6月发表的已识别研究的参考文献和会议摘要。从纳入的研究中提取有关参与者总数、第一作者、国家、病程、对照数量、患者平均年龄、男性和女性数量、平均扩展残疾状态量表（EDSS）以及患有RLS的病例和/或对照数量的数据。
结果
文献检索共发现855篇文章；删除重复项后，剩余530篇。纳入荟萃分析的有75项研究（图1）。在6篇文章中，作者在报告RLS病例时未区分临床孤立综合征（CIS）和MS病例。总共评估了15411例MS/CIS患者，其中4309例患有RLS。RLS的合并患病率为28%（95%置信区间：24 - 33%）。男性RLS的合并患病率为22%（95%置信区间：17 - 26%），女性RLS的合并患病率为30%（95%置信区间：25 - 35%）。对照中RLS的合并患病率为8%（95%置信区间：6 - 10%）。
结论
本系统评价和荟萃分析的结果表明，MS病例中RLS的合并患病率为28%，对照中为8%。女性的合并患病率高于男性（30%对22%）。
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