Department of Biochemistry, Riphah International University, Faisalabad, 38000, Pakistan.
Department of Pharmacy, Riphah International University, Faisalabad, 38000, Pakistan.
Environ Sci Pollut Res Int. 2022 Oct;29(47):70808-70821. doi: 10.1007/s11356-022-22779-2. Epub 2022 Sep 5.
Pollution is a significant and growing concern for any population regardless of age because these environmental contaminants exhibit different neurodegenerative effects on persons of different ages. These environmental contaminants are the products of human welfare projects like industry, automobile exhaust, clinical and research laboratory extrudes, and agricultural chemicals. These contaminants are found in various forms in environmental matrices like nanoparticles, particulate matter, lipophilic vaporized toxicants, and ultrafine particulate matter. Because of their small size, they can easily cross blood-brain barriers or use different cellular mechanisms for assistance. Other than this, these contaminants cause an innate immune response in different cells of the central nervous system and cause neurotoxicity. Considering the above critiques and current needs, this review summarizes different protective strategies based on bioactive compounds present in plants. Various bioactive compounds from medicinal plants with neuroprotective capacities are discussed with relevant examples. Many in vitro studies on clinical trials have shown promising outcomes using plant-based bioactive compounds against neurological disorders.
污染是一个无论年龄大小的人群都应关注的重要且日益严重的问题，因为这些环境污染物对不同年龄段的人表现出不同的神经退行性影响。这些环境污染物是工业、汽车尾气、临床和研究实验室挤压物以及农业化学品等人类福利项目的产物。这些污染物以纳米颗粒、颗粒物、亲脂性挥发毒物和超细颗粒物等形式存在于各种环境基质中。由于它们的体积小，它们可以轻易地穿过血脑屏障或利用不同的细胞机制进行协助。除此之外，这些污染物会在中枢神经系统的不同细胞中引起固有免疫反应，并导致神经毒性。鉴于上述批评和当前的需求，本综述根据植物中存在的生物活性化合物总结了不同的保护策略。讨论了具有神经保护能力的药用植物中的各种生物活性化合物，并提供了相关实例。许多针对临床试验的体外研究表明，使用基于植物的生物活性化合物对抗神经紊乱具有有前景的结果。
