Kim Hyun Jung, Chung Ju-Hye, Eun Youngmi, Kim Se-Hong
Department of Family Medicine, Graduate School of The Catholic University of Korea, Seoul, Republic of Korea.
Department of Family Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Psychiatry Investig. 2022 Aug;19(8):695-701. doi: 10.30773/pi.2022.0200. Epub 2022 Aug 24.
We aimed to explore the impact of sarcopenia on the cortical thickness, white matter hyperintensity (WMH), and subcortical volumes in the cognitively normal older adults.
Sixty cognitively normal older adults with and without sarcopenia were enrolled in the study. They underwent T1 and FLAIR magnetic resonance imaging. Information on muscle mass, muscle strength and muscle function were measured using bioelectrical impedance analysis, handgrip strength and 5 time-chair stand test (CST) respectively. Structural magnetic resonance images were analyzed and processed using Freesurfer v6.0.
Compared to the control group, the sarcopenia group demonstrated reduced cortical thickness in left superior frontal, precentral, right post central, inferior parietal, rostral middle frontal superior parietal and both lateral occipital and paracentral gyrus. Volumes of left hippocampus, and periventricular WMH were also reduced in the Sarcopenia group. In addition, we found a significant positive correlation between the left precuneus thickness and muscle mass. Periventricular WMH volumes were also positively correlated with the 5CST score.
Sarcopenia affects cortical and subcortical structures in the cognitively normal older adults. These structural changes might be associated with underlying neurobiological mechanisms of sarcopenia in the cognitively normal older adults.
我们旨在探讨肌肉减少症对认知功能正常的老年人皮质厚度、白质高信号（WMH）和皮质下体积的影响。
60名有或无肌肉减少症的认知功能正常的老年人参与了本研究。他们接受了T1和液体衰减反转恢复序列（FLAIR）磁共振成像。分别使用生物电阻抗分析、握力和5次起坐试验（CST）测量肌肉质量、肌肉力量和肌肉功能信息。使用Freesurfer v6.0对结构磁共振图像进行分析和处理。
与对照组相比，肌肉减少症组在左侧额上回、中央前回、右侧中央后回、顶下小叶、额中回喙部、顶上小叶以及双侧枕外侧回和中央旁回的皮质厚度降低。肌肉减少症组左侧海马体积和脑室周围WMH也减少。此外，我们发现左侧楔前叶厚度与肌肉质量之间存在显著正相关。脑室周围WMH体积也与5次起坐试验（5CST）评分呈正相关。
肌肉减少症影响认知功能正常的老年人的皮质和皮质下结构。这些结构变化可能与认知功能正常的老年人肌肉减少症的潜在神经生物学机制有关。
