Trollfors Birger, Melin Fredrik, Gudjonsdottir Margret Johansson, Rupröder Rebecca, Sandin Milen, Dahl Mats, Karlsson Johanna, Backhaus Erik
Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden and University of Gothenburg, Gothenburg, Sweden.
Department of Infectious Diseases, Skaraborg Hospital, Skövde, Sweden.
IJID Reg. 2022 Aug 7;4:171-175. doi: 10.1016/j.ijregi.2022.08.002. eCollection 2022 Sep.
This was a retropective study of invasive group B streptococcal (GBS) infections isolated from blood, cerebrospinal fluid (CSF), synovial fluid, peritoneal fluid, pleural fluid, pericardial fluid and corpus vitreum in a defined region in southwest Sweden over a 14-year period.
Information on all invasive GBS infections was obtained from all four bacteriological laboratories in the region, with data obtained from individual patient records.
GBS was isolated from normally sterile body fluids in 1244 samples (579 from females and 665 from males) from 1101 patients. Of these patients, 196 were neonates. The incidence in neonates (0-27 days) was 7.3 per 100 000 live births per year, but there was a significant decrease from 2012 when risk-factor-based intrapartum antibibiotic prophylaxis was implemented. The great majority of neonatal infections were very early-onset infections. The incidence rates in children (28 days to 17 years), adults (18-64 years) and elderly patients (≥ 65 years) were 1.3, 3.6, and 12.9 per 100 000 per year, respectively. The majority of children and adults had severe underlying diseases, but severe infections were also seen in individuals with no risk factors.
GBS is an important pathogen in all age groups. Intrapartum antibiotic prophylaxis significantly decreases very early-onset infections.
这是一项回顾性研究，对瑞典西南部某特定地区14年间从血液、脑脊液、滑液、腹腔液、胸腔液、心包液和玻璃体中分离出的B族链球菌（GBS）侵袭性感染进行研究。
从该地区所有四个细菌学实验室获取所有侵袭性GBS感染的信息，数据来自个体患者记录。
从1101例患者的1244份样本（579份来自女性，665份来自男性）的正常无菌体液中分离出GBS。其中，196例为新生儿。新生儿（0 - 27天）的发病率为每年每10万活产7.3例，但自2012年实施基于风险因素的产时抗生素预防措施后显著下降。绝大多数新生儿感染为早发型感染。儿童（28天至17岁）、成人（18 - 64岁）和老年患者（≥65岁）的发病率分别为每年每10万1.3例、3.6例和12.9例。大多数儿童和成人患有严重的基础疾病，但无风险因素的个体也出现了严重感染。
GBS是所有年龄组中的重要病原体。产时抗生素预防措施显著降低了早发型感染。
