Nassiri Nariman, Mei Frank, Tokko Hassan, Zeiter John, Syeda Sarah, Kim Chaesik, Swendris Ronald, Goyal Anju, Veld Elise In'T, Mas-Ramirez Alma, Rana Sonia W, Juzych Mark S, Hughes Bret A
Department of Ophthalmology, Kresge Eye Institute, Detroit, Michigan, United States.
School of Medicine, Wayne State University, Detroit, Michigan, United States.
J Curr Glaucoma Pract. 2022 Jan-Apr;16(1):36-40. doi: 10.5005/jp-journals-10078-1361.
"Consensual ophthalmotonic reaction" refers to changes in intraocular pressure (IOP) in one eye, which is accompanied by a corresponding change in IOP in the contralateral eye. This study evaluates whether monocular administration of selective laser trabeculoplasty (SLT) leads to a consensual ophthalmotonic reaction and how long this effect lasts.
A retrospective chart review was performed on patients receiving SLT at Kresge Eye Institute in Detroit, MI, from January 2015 to August 2016. Patients were excluded if they had previous history of glaucoma incisional and/or laser procedures; required additional laser trabeculoplasty; had glaucoma medication changes during the follow-up period; experienced no decrease in IOP during the follow-up period; or had a diagnosis of angle closure on gonioscopy. Various demographic, clinical, and surgical data were collected. IOP measurements were collected at baseline and postoperatively at 1-3 months, 4-9 months, and 12-15 months.
At all follow-up periods, the IOP of the treated eye was decreased from baseline IOP ( ≤ 0.05, paired -test). For the fellow eye, there was a statistically significantly decrease from baseline up to the 4-9 months follow-up period ( ≤ 0.05, paired -test). Linear regression analysis of the percent reduction in IOP from baseline in the SLT-treated eye with the fellow eye shows a mild correlation at all-time points: R = 0.284 ( < 0.001) at 1-3 months; R = 0.348 ( < 0.001) at 4-9 months; R = 0.118 ( = 0.054) at 12-15 months.
This study showed that monocular administration of SLT results in a consensual ophthalmotonic reaction. The consensual ophthalmotonic reaction appears to last for up to 4-9 months.
Therefore, although SLT does lead to a consensual ophthalmotonic reaction, monocular administration of SLT is not a reliable method of long-term IOP control for the contralateral non-SLT-treated eye.
Nassiri N, Mei F, Tokko H, Consensual Ophthalmotonic Reaction Following Selective Laser Trabeculoplasty. J Curr Glaucoma Pract 2022;16(1):36-40.
“交感眼内压反应”是指一只眼睛的眼内压（IOP）发生变化，同时对侧眼睛的眼内压也出现相应变化。本研究评估单眼选择性激光小梁成形术（SLT）是否会导致交感眼内压反应以及这种效应持续多长时间。
对2015年1月至2016年8月在密歇根州底特律市克雷斯吉眼科研究所接受SLT治疗的患者进行回顾性病历审查。如果患者有青光眼切开和/或激光手术史；需要额外的激光小梁成形术；在随访期间青光眼药物治疗有变化；在随访期间眼内压未降低；或在房角镜检查中诊断为闭角型青光眼，则将其排除。收集了各种人口统计学、临床和手术数据。在基线以及术后1 - 3个月、4 - 9个月和12 - 15个月收集眼内压测量值。
在所有随访期间，治疗眼的眼内压均较基线眼内压降低（配对t检验，P≤0.05）。对于对侧眼，在4 - 9个月的随访期内，与基线相比眼内压有统计学意义的降低（配对t检验，P≤0.05）。对SLT治疗眼和对侧眼基线眼内压降低百分比进行线性回归分析，结果显示在所有时间点均有轻度相关性：1 - 3个月时R = 0.284（P < 0.001）；4 - 9个月时R = 0.348（P < 0.001）；12 - 15个月时R = 0.118（P = 0.054）。
本研究表明单眼SLT会导致交感眼内压反应。交感眼内压反应似乎可持续长达4 - 9个月。
因此，尽管SLT确实会导致交感眼内压反应，但单眼SLT并非对侧未接受SLT治疗眼长期控制眼内压的可靠方法。
Nassiri N, Mei F, Tokko H, 选择性激光小梁成形术后的交感眼内压反应。《当代青光眼实践杂志》2022；16(1):36 - 40。
