Nassiri Nariman, Das Shibandri, Patel Vaama, Nirmalan Aravindh, Patwa Dhir, Heriford Alexandra, Kim Chaesik, Chen Haoxing, Ridha Faisal, Tannir Justin, Goyal Anju, Juzych Mark S, Hughes Bret A
Ophthalmology, Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan, United States.
Wayne State University School of Medicine, Detroit, Michigan, United States.
J Curr Glaucoma Pract. 2022 Jan-Apr;16(1):11-16. doi: 10.5005/jp-journals-10078-1350.
Using demographic, clinical, visual field, and optical coherence tomography (OCT) variables to study the association of 5-year glaucomatous progression in glaucoma suspect eyes.
This is a retrospective longitudinal clinical study. Inclusion criteria consisted of glaucoma suspect eyes (i.e., concerning cup-to-disk ratio and/or intraocular pressure (IOP) >21 mm Hg), age ≥ 30 years old, follow-up time of 5 years, best-corrected visual acuity (BCVA) of 20/100 or better, spherical equivalent (SE) higher than 8 diopters and an astigmatism less than 3 diopters. Eyes with glaucoma-determined by two consecutive, reliable visual field tests-were excluded, as well as any eyes with any clinically significant retinal or neurological disease. The percentage of glaucoma suspect eyes, which progressed to glaucoma within a 5-year period, was calculated. Study subjects were divided into the following groups: eyes that progressed to glaucoma and those that did not.
In the 288 patients which we looked at, 365 total eyes, 323 eyes had concerning cup-to-disk ratio and 42 had ocular hypertension. Bivariate analysis showed that the eyes which progressed to glaucoma had significantly worse mean deviation, increased pattern standard deviation (PSD), and less visual field index (VFI). Our bivariate analysis also showed a thinner average, superior and inferior retinal nerve fiber layer thickness (RNFL), and more severe average, superior, and inferior RNFL damages (i.e., color grading scale) at baseline. Logistic regression analysis showed that only PSD and severe inferior RNFL damage (i.e., red color) to be significantly associated with 5-year glaucomatous progression.
Segmental RNFL damage and pattern standard deviation are associated with 5-year glaucomatous progression in glaucoma suspect eyes.
Nassiri N, Das S, Patel V, Factors Associated with 5-year Glaucomatous Progression in Glaucoma Suspect Eyes: A Retrospective Longitudinal Study. J Curr Glaucoma Pract 2022;16(1):11-16.
利用人口统计学、临床、视野及光学相干断层扫描（OCT）变量研究青光眼可疑眼5年青光眼进展的相关性。
这是一项回顾性纵向临床研究。纳入标准包括青光眼可疑眼（即杯盘比可疑和/或眼压（IOP）>21 mmHg）、年龄≥30岁、随访时间5年、最佳矫正视力（BCVA）为20/100或更好、等效球镜度（SE）高于8屈光度且散光小于3屈光度。通过连续两次可靠的视野检查确诊为青光眼的眼以及任何患有具有临床意义的视网膜或神经疾病的眼均被排除。计算青光眼可疑眼在5年内进展为青光眼的百分比。研究对象分为以下几组：进展为青光眼的眼和未进展为青光眼的眼。
在我们观察的288例患者中，共有365只眼，其中323只眼杯盘比可疑，42只眼患有高眼压症。二元分析显示，进展为青光眼的眼平均偏差明显更差，模式标准差（PSD）增加，视野指数（VFI）更低。我们的二元分析还显示，基线时平均、上方和下方视网膜神经纤维层厚度（RNFL）更薄，平均、上方和下方RNFL损伤（即颜色分级量表）更严重。逻辑回归分析显示，只有PSD和严重的下方RNFL损伤（即红色）与5年青光眼进展显著相关。
节段性RNFL损伤和模式标准差与青光眼可疑眼5年青光眼进展相关。
纳西里N，达斯S，帕特尔V，青光眼可疑眼5年青光眼进展的相关因素：一项回顾性纵向研究。《当代青光眼实践杂志》2022；16（1）：11 - 16。
