Dorairaj Syril, Radcliffe Nathan M, Grover Davinder S, Brubaker Jacob W, Williamson Blake K
Department of Ophthalmology, Mayo Clinic College of Medicine, Jacksonville, Florida, United States.
Department of Ophthalmology, Mount Sinai School of Medicine, New York, United States.
J Curr Glaucoma Pract. 2022 Jan-Apr;16(1):59-64. doi: 10.5005/jp-journals-10078-1352.
To review the published literature describing clinical outcomes of excisional goniotomy using the Kahook Dual Blade (KDB) for the management of glaucoma.
A family of less invasive glaucoma procedures-including excisional goniotomy with the KDB-has been developed to provide moderate reductions in intraocular pressure and/or medication burden in eyes with therapeutic needs that may not warrant the risks associated with more traditional procedures such as trabeculectomy and tube-shunt implantation. This review's goal is to synthesize the existing literature into a compendium of excisional goniotomy's indications, technique, efficacy and safety outcomes, and optimal place in glaucoma management.
Excisional goniotomy with the KDB effectively lowers IOP and reduces the medication burden in eyes with POAG and other forms of glaucoma across the spectrum of both baseline IOP and disease severity. The procedure exhibits a safety profile that is on par with other angle-based surgical interventions and enhanced safety compared to filtration procedures. It can be performed by comprehensive ophthalmologists as well as glaucoma specialists. This procedure as a standalone operation delivers IOP reductions consistent with filtration surgery, and in combination with cataract surgery delivers both IOP and medication reductions at least as great as other minimally invasive procedures.
Given the broad base of evidence supporting its use in a wide variety of clinical scenarios, excisional goniotomy with the KDB can play a meaningful role in the achievement of patient-specific glaucoma therapy goals.
These aggregate findings support the efficacy and safety of excisional goniotomy with the KDB and clarify the patient profiles best suited for this procedure.
Dorairaj S, Radcliffe NM, Grover DS, A Review of Excisional Goniotomy Performed with the Kahook Dual Blade for Glaucoma Management. J Curr Glaucoma Pract 2022;16(1):59-64.
回顾已发表的文献,这些文献描述了使用卡胡克双刃刀(KDB)进行切开性房角切开术治疗青光眼的临床结果。
已开发出一系列侵入性较小的青光眼手术,包括使用KDB进行切开性房角切开术,以适度降低有治疗需求但可能无法承受小梁切除术和引流管植入术等更传统手术相关风险的眼睛的眼压和/或药物负担。本综述的目的是将现有文献综合成一份关于切开性房角切开术的适应证、技术、疗效和安全性结果以及在青光眼治疗中的最佳地位的纲要。
使用KDB进行切开性房角切开术可有效降低原发性开角型青光眼(POAG)和其他形式青光眼患者的眼压,并减轻其药物负担,无论基线眼压和疾病严重程度如何。该手术的安全性与其他基于房角的手术干预相当,与滤过性手术相比安全性更高。综合眼科医生和青光眼专科医生均可进行此手术。作为独立手术,该手术降低眼压的效果与滤过性手术相当,与白内障手术联合使用时,降低眼压和减少药物使用的效果至少与其他微创青光眼手术一样好。
鉴于有广泛的证据支持其在各种临床场景中的应用,使用KDB进行切开性房角切开术可在实现个体化青光眼治疗目标方面发挥重要作用。
这些综合研究结果支持使用KDB进行切开性房角切开术的有效性和安全性,并明确了最适合该手术的患者特征。
多拉伊拉杰S、拉德克利夫NM、格罗弗DS,《使用卡胡克双刃刀进行切开性房角切开术治疗青光眼的综述》。《当代青光眼实践杂志》2022年;16(1):59 - 64。