Olsen Maria Belland, Sannes Ann-Christin, Yang Kuan, Nielsen Morten Birkeland, Einarsen Ståle Valvatne, Christensen Jan Olav, Pallesen Ståle, Bjørås Magnar, Gjerstad Johannes
Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.
Faculty of Medicine, University of Oslo, Oslo, Norway.
iScience. 2022 Aug 17;25(9):104953. doi: 10.1016/j.isci.2022.104953. eCollection 2022 Sep 16.
Environmental stressors such as repeated social defeat may initiate powerful activation of subconscious parts of the brain. Here, we examine the consequences of such stress (induced by resident-intruder paradigm) on the pituitary gland. In male stressed vs. control rats, by RNA- and bisulfite DNA sequencing, we found regulation of genes involved in neuron morphogenesis and communication. Among these, () showed reduced transcription and reduced DNA methylation in a region corresponding to intron 1 in human . Also, genetic variability in this area was associated with altered stress response in male humans exposed to repeated social defeat in the form of abusive supervision. Thus, our data show that the pituitary gene expression may be affected by social stress and that genetic variability in intron 1 region influences stress-induced negative emotions. We hope our shared datasets will facilitate further exploration of the motions triggered by social stressors.
诸如反复遭受社会挫败等环境应激源可能会引发大脑潜意识部分的强烈激活。在此，我们研究了这种应激（由定居者-入侵者范式诱导）对垂体的影响。在雄性应激大鼠与对照大鼠中，通过RNA测序和亚硫酸氢盐DNA测序，我们发现了参与神经元形态发生和通讯的基因调控。其中，（）在与人类（）内含子1相对应的区域显示转录减少和DNA甲基化降低。此外，该区域的基因变异性与遭受辱骂性监督形式的反复社会挫败的男性人类的应激反应改变有关。因此，我们的数据表明垂体基因表达可能受社会应激影响，且（）内含子1区域的基因变异性影响应激诱导的负面情绪。我们希望我们共享的数据集将有助于进一步探索由社会应激源引发的情绪。
