Sannes Ann-Christin, Christensen Jan Olav, Nielsen Morten Birkeland, Gjerstad Johannes
National Institute of Occupational Health, Norway, Oslo, Norway.
Scand J Pain. 2022 Oct 3;23(2):326-332. doi: 10.1515/sjpain-2022-0094. Print 2023 Apr 25.
Earlier findings suggest that social stress such as abusive supervision may promote pain. In the present study we examine the possible moderating role of genetic variability in the gene in this process.
The data were collected through a national survey drawn from the National Central Employee Register by Statistics Norway. A total of 1,205 individuals returned both the questionnaire and the saliva kit. Abusive supervision was scored by a 5-item version of the Tepper's 2,000 scale. Headache was measured on a four-category scale; 'not bothered,' 'a little bothered,' 'considerably bothered', 'seriously bothered'. Genotyping with regards to NRCAM rs2300043 was carried out using Taqman assay. Ordinal logistic regression was used to analyse the data.
For males exposed to abusive supervision, those carrying the rs2300043 CC genotype reported the highest levels of headache. Women showed a trend towards the opposite pattern. Women with the rs2300043 CC genotype seem to have a weaker effect of abusive supervision regarding reported headache than their male counterparts with the CC genotype when exposed to abusive supervision.
The present results indicated that the association between abusive supervision and headache in men with the NRCAM rs2300043 C allele was stronger than in other men. This suggests that the NRCAM genotype in men is important for the tolerance of social stress e.g., repeated negative acts from a superior. In contrast, a trend, though non-significant, towards the opposite pattern was observed in women. Our result suggests that the NRCAM genotype in men manifestly affects stress-induced pain such as headache.
早期研究结果表明，诸如辱骂性监督等社会压力可能会加剧疼痛。在本研究中，我们探讨了该基因的基因变异在这一过程中可能起到的调节作用。
数据通过挪威统计局从国家中央员工登记册中抽取的全国性调查收集。共有1205人同时返还了问卷和唾液样本采集试剂盒。辱骂性监督采用特珀2000量表的5项版本进行评分。头痛程度用四类量表进行测量：“未受困扰”、“有点困扰”、“相当困扰”、“严重困扰”。使用Taqman分析法对NRCAM rs2300043进行基因分型。采用有序逻辑回归分析数据。
对于遭受辱骂性监督的男性，携带rs2300043 CC基因型的人报告的头痛程度最高。女性呈现出相反的趋势。rs2300043 CC基因型的女性在遭受辱骂性监督时，其报告的头痛程度受辱骂性监督的影响似乎比携带CC基因型的男性同行要小。
目前的结果表明，携带NRCAM rs2300043 C等位基因的男性中，辱骂性监督与头痛之间的关联比其他男性更强。这表明男性的NRCAM基因型对于承受社会压力（例如上级反复的负面行为）很重要。相比之下，女性中观察到了相反模式，但不显著。我们的结果表明，男性的NRCAM基因型明显影响压力诱发的疼痛，如头痛。
