Jha Manish, Tak M L, Gupta Rashmi, Sharma Priyamvada, Rajpurohit Vikas, Mathur Prachi, Gaur Nayanika
Department of Anesthesia, Dr. S. N. Medical College and Associated Hospitals, Jodhpur, Rajasthan, India.
Department of Obstetrics and Gynecology, Kirti IVF Clinic, Jodhpur, Rajasthan, India.
J Anaesthesiol Clin Pharmacol. 2022 Jul;38(Suppl 1):S115-S119. doi: 10.4103/joacp.joacp_63_22. Epub 2022 Jun 15.
With the second wave of COVID-19, India lost close to three lakh people within the span of a few months. In this study, we aimed to investigate the impact of anemia on the severity of COVID-19 based on the hemoglobin (Hb) concentration of the patients noted at the time of admission to the intensive care unit (ICU), to mark Hb as a prognostic marker of disease severity for the future.
Retrospective data was collected from 784 patients admitted to the COVID adult ICU between March and June 2021. Patients were identified as anemic and non-anemic based on the World Health Organization (WHO) guidelines. Chi-squared test was applied to see the relationship of anemia with the patient deaths.
Among the 784 patients, 507 succumbed to COVID-19. Of these, 49.3% had varying degrees of anemia. Significant correlation of anemia with death due to COVID-19 was found in males and females (P = 0.002106 and P = 0.033071, respectively) and in patients without any other comorbidities except anemia (P = 0.002020). This suggests that anemia is independently an important parameter that plays a role in severity of COVID-19.
Upon observing a significant correlation between anemia and COVID-19 severity, it can be stated that anemia should be considered as an independent prognostic risk factor for COVID-19 and that hemoglobin can be used for risk stratification in patients under home or hospital care.
在新冠疫情第二波期间，印度在短短几个月内有近30万人死亡。在本研究中，我们旨在根据患者入住重症监护病房（ICU）时记录的血红蛋白（Hb）浓度，调查贫血对新冠病情严重程度的影响，以便将Hb作为未来疾病严重程度的预后指标。
收集了2021年3月至6月期间入住新冠成人ICU的784例患者的回顾性数据。根据世界卫生组织（WHO）指南，将患者分为贫血组和非贫血组。采用卡方检验观察贫血与患者死亡之间的关系。
在784例患者中，507例死于新冠。其中，49.3%患有不同程度的贫血。在男性和女性患者中（分别为P = 0.002106和P = 0.033071）以及除贫血外无任何其他合并症的患者中（P = 0.002020），均发现贫血与新冠死亡存在显著相关性。这表明贫血是独立于其他因素之外，在新冠严重程度中起作用的重要参数。
鉴于观察到贫血与新冠严重程度之间存在显著相关性，可以认为贫血应被视为新冠的独立预后风险因素，血红蛋白可用于居家或住院治疗患者的风险分层。
