Drummond P D, Boyce G M, Lance J W
Ann Neurol. 1987 Jun;21(6):559-63. doi: 10.1002/ana.410210606.
An 11-year-old girl who had suffered right facial herpes zoster at the age of 6 years was left with anesthetic scars in the distribution of the third division of the trigeminal nerve. Since then, certain tastes provoked flushing and sweating localized to the scarred areas, lasting for 10 to 15 minutes after a latency of a few seconds. The response was evoked most readily from the ipsilateral posterior section of the tongue and was virtually abolished by local administration of anesthesia to the tongue. It remained unaltered after blockade of the sphenopalatine and stellate ganglia but was diminished by blockade of the mandibular nerve. Thermoregulatory sweating and flushing were diminished in the scarred areas. Patchy destruction of sympathetic fibers, which are known to accompany peripheral trigeminal nerve branches, and reinnervation of the affected areas by parasympathetic fibers that normally mediate salivation may explain the phenomenon. It is thus analogous to the gustatory flushing and sweating that may follow damage to the auriculotemporal nerve in the region of the parotid gland (Frey's syndrome).
一名11岁女孩在6岁时患右侧面部带状疱疹，在三叉神经第三支分布区域留下了麻醉性瘢痕。从那时起，某些味觉会引发瘢痕区域的脸红和出汗，潜伏期为几秒，持续10至15分钟。这种反应最容易从同侧舌后部诱发，局部麻醉舌头后几乎完全消失。蝶腭神经节和星状神经节阻滞对此反应无影响，但下颌神经阻滞可使其减弱。瘢痕区域的体温调节性出汗和脸红减少。已知伴随周围三叉神经分支的交感神经纤维的片状破坏，以及通常介导唾液分泌的副交感神经纤维对受影响区域的重新支配，可能解释了这一现象。因此，它类似于腮腺区域耳颞神经损伤后可能出现的味觉性脸红和出汗（弗雷综合征）。
