Department of Pulmonary and Critical Care Medicine, The Ninth Hospital of Xi'an Affiliated with Xi'an Jiaotong University, Xi'an, Shaanxi 710054, China.
Department of Epidemiology and Biostatistics School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China.
Can Respir J. 2022 Aug 24;2022:4201786. doi: 10.1155/2022/4201786. eCollection 2022.
Impairment of pulmonary function was evaluated in chronic bronchitis patients with preserved ratio impaired spirometry (PRISm). We retrospectively collected clinical data from 157 chronic bronchitis (CB) and 186 chronic obstructive pulmonary disease (COPD) patients between October 2014 and September 2017. These patients were assigned to three groups: control (normal pulmonary function), PRISm (forced expiratory volume in 1 second [FEV1]/forced vital capacity [FVC] ≥ 0.7, FEV1 < 80% of predicted value), and COPD (FEV1/FVC <0.7) groups. Because small airway function was the main focus, in the COPD group, only patients in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 1 and 2 were included. Evaluation of pulmonary function (including impulse oscillometry) was performed and compared among these groups. Compared with the control group, the PRISm and COPD groups showed statistically significant differences in the predicted FEV1% ( < 0.001), maximal expiratory flow (MEF) 25% ( < 0.001), MEF50% ( < 0.001), maximal midexpiratory flow (MMEF) 25-75% ( < 0.001), residual volume (RV)/total lung capacity (TLC; < 0.001), FVC% ( < 0.001), total respiratory resistance and proximal respiratory resistance (R5-R20; < 0.001), respiratory system reactance at 5 Hz (X5; < 0.001), resonant frequency (Fres; < 0.001), and area of reactance (Ax; < 0.001). However, the predicted FEV1% and RV/TLC were similar between the PRISm and COPD groups (=0.992 and 0.122, respectively). PRISm is a nonspecific pattern of pulmonary function that indicates small airway dysfunction and may increase the risk of transformation to obstructive ventilation dysfunction. This trial is registered with ChiCTR-OCH-14004904.
在保留比受损肺活量测定法（PRISm）的慢性支气管炎患者中评估了肺功能障碍。我们回顾性地收集了 2014 年 10 月至 2017 年 9 月期间 157 例慢性支气管炎（CB）和 186 例慢性阻塞性肺疾病（COPD）患者的临床数据。这些患者被分为三组：对照组（正常肺功能）、PRISm 组（第 1 秒用力呼气量[FEV1]/用力肺活量[FVC]≥0.7，FEV1<80%预计值）和 COPD 组（FEV1/FVC<0.7）。由于主要关注小气道功能，在 COPD 组中，仅纳入符合全球慢性阻塞性肺疾病倡议（GOLD）1 级和 2 级的患者。在这些组之间进行了肺功能（包括脉冲振荡）评估和比较。与对照组相比，PRISm 组和 COPD 组的预计 FEV1%（<0.001）、最大呼气流量（MEF）25%（<0.001）、MEF50%（<0.001）、最大中呼气流量（MMEF）25-75%（<0.001）、残气量（RV）/总肺活量（TLC；<0.001）、FVC%（<0.001）、总呼吸阻力和近端呼吸阻力（R5-R20；<0.001）、5Hz 呼吸阻抗（X5；<0.001）、共振频率（Fres；<0.001）和电抗面积（Ax；<0.001）均存在统计学差异。然而，PRISm 组和 COPD 组的预计 FEV1%和 RV/TLC 相似（=0.992 和 0.122）。PRISm 是一种肺功能的非特异性模式，表明小气道功能障碍，可能增加向阻塞性通气功能障碍转化的风险。该试验在中国临床试验注册中心注册，注册号为 ChiCTR-OCH-14004904。
