Farnudian-Habibi Amir, Mirjani Mobina, Montazer Vahideh, Aliebrahimi Shima, Katouzian Iman, Abdolhosseini Saeed, Rahmani Ali, Keyvani Hossein, Ostad Seyed Nasser, Rad-Malekshahi Mazda
Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Pharm Res. 2022 Jan 24;21(1):e124228. doi: 10.5812/ijpr.124228. eCollection 2022 Dec.
The last generation of Coronavirus named COVID-19 is responsible for the recent worldwide outbreak. Concerning the widespread and quick predominance, there is a critical requirement for designing appropriate vaccines to surmount this grave problem. Correspondingly, in this revision, COVID-19 vaccines (which are being developed until March 29th, 2021) are classified into specific and non-specific categories. Specific vaccines comprise genetic-based vaccines (, ), vector-based, protein/recombinant protein vaccines, inactivated viruses, live-attenuated vaccines, and novel strategies including microneedle arrays (), and nanoparticles vaccines. Moreover, specific vaccines such as , , and a few other vaccines are considered Non-specific. What is more, according to the significance of Bioinformatic sciences in the cutting-edge vaccine design and rapid outbreak of COVID-19, herein, Bioinformatic principles including reverse vaccinology, epitopes prediction/selection and, their further applications in the design of vaccines are discussed. Last but not least, safety, challenges, advantages, and future prospects of COVID-19 vaccines are highlighted.
名为COVID-19的上一代冠状病毒是近期全球疫情爆发的罪魁祸首。鉴于其广泛且迅速的传播，迫切需要设计合适的疫苗来解决这一严重问题。相应地，在本次综述中，COVID-19疫苗（截至2021年3月29日正在研发的疫苗）被分为特异性和非特异性两类。特异性疫苗包括基于基因的疫苗（，）、基于载体的疫苗、蛋白质/重组蛋白疫苗、灭活病毒疫苗、减毒活疫苗，以及包括微针阵列（）和纳米颗粒疫苗在内的新型策略。此外，诸如，，以及其他一些疫苗被视为非特异性疫苗。更重要的是，鉴于生物信息科学在前沿疫苗设计中的重要性以及COVID-19的迅速爆发，本文讨论了包括反向疫苗学、表位预测/选择在内的生物信息学原理及其在疫苗设计中的进一步应用。最后但同样重要的是，强调了COVID-19疫苗的安全性、挑战、优势和未来前景。
