Matsuzaka Yasunari, Yashiro Ryu
Division of Molecular and Medical Genetics, The Institute of Medical Science, Center for Gene and Cell Therapy, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
Administrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan.
Vaccines (Basel). 2023 Feb 24;11(3):539. doi: 10.3390/vaccines11030539.
Messenger ribonucleic acid (RNA) vaccines are mainly used as SARS-CoV-2 vaccines. Despite several issues concerning storage, stability, effective period, and side effects, viral vector vaccines are widely used for the prevention and treatment of various diseases. Recently, viral vector-encapsulated extracellular vesicles (EVs) have been suggested as useful tools, owing to their safety and ability to escape from neutral antibodies. Herein, we summarize the possible cellular mechanisms underlying EV-based SARS-CoV-2 vaccines.
信使核糖核酸（RNA）疫苗主要用作严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗。尽管存在一些关于储存、稳定性、有效期和副作用的问题，但病毒载体疫苗仍被广泛用于预防和治疗各种疾病。最近，由于其安全性和能够逃避中和抗体，病毒载体封装的细胞外囊泡（EVs）被认为是有用的工具。在此，我们总结了基于EV的SARS-CoV-2疫苗潜在的细胞机制。
