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姜黄素-黄芩素联合对糖尿病血管病变大血管变化的保护作用。

Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy.

机构信息

Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China.

NICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia.

出版信息

Front Endocrinol (Lausanne). 2022 Aug 18;13:953305. doi: 10.3389/fendo.2022.953305. eCollection 2022.

DOI:10.3389/fendo.2022.953305
PMID:36060932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9433877/
Abstract

Endothelial dysfunction is an early pathological event in diabetic angiopathy which is the most common complication of diabetes. This study aims to investigate individual and combined actions of Curcumin (Cur) and Baicalein (Bai) in protecting vascular function. The cellular protective effects of Cur, Bai and Cur+Bai (1:1, ) were tested in HO (2.5 mM) impaired EA. hy926 cells. Wistar rats were treated with vehicle control as the control group, Goto-Kakizaki rats (n=5 each group) were treated with vehicle control (model group), Cur (150 mg/kg), Bai (150 mg/kg), or Cur+Bai (75 mg/kg Cur + 75 mg/kg Bai, OG) for 4 weeks after a four-week high-fat diet to investigate the changes on blood vessel against diabetic angiopathy. Our results showed that Cur+Bai synergistically restored the endothelial cell survival and exhibited greater effects on lowering the fasting blood glucose and blood lipids in rats comparing to individual compounds. Cur+Bai repaired the blood vessel structure in the aortic arch and mid thoracic aorta. The network pharmacology analysis showed that Nrf2 and MAPK/JNK kinase were highly relevant to the multi-targeted action of Cur+Bai which has been confirmed in the and studies. In conclusion, Cur+Bai demonstrated an enhanced activity in attenuating endothelial dysfunction against oxidative damage and effectively protected vascular function in diabetic angiopathy rats.

摘要

内皮功能障碍是糖尿病血管病变的早期病理事件，也是糖尿病最常见的并发症。本研究旨在探讨姜黄素（Cur）和白杨素（Bai）单独和联合作用对血管功能的保护作用。在 HO（2.5 mM）损伤的 EA.hy926 细胞中测试了 Cur、Bai 和 Cur+Bai（1:1， ）的细胞保护作用。Wistar 大鼠用载体对照作为对照组，Goto-Kakizaki 大鼠（每组 5 只）用载体对照（模型组）、Cur（150 mg/kg）、Bai（150 mg/kg）或 Cur+Bai（75 mg/kg Cur + 75 mg/kg Bai，OG）治疗 4 周，在高脂肪饮食 4 周后，研究其对血管的变化。我们的结果表明，Cur+Bai 协同恢复内皮细胞存活，并对降低大鼠空腹血糖和血脂表现出比单独化合物更大的作用。Cur+Bai 修复了主动脉弓和胸中段主动脉的血管结构。网络药理学分析表明，Nrf2 和 MAPK/JNK 激酶与 Cur+Bai 的多靶点作用高度相关，这已在 和 研究中得到证实。总之，Cur+Bai 在减轻氧化损伤引起的内皮功能障碍方面表现出增强的活性，并有效保护糖尿病血管病变大鼠的血管功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/7d2306c41868/fendo-13-953305-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/82e3e778989e/fendo-13-953305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/8a9e6e0a448c/fendo-13-953305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/1d705f02fa42/fendo-13-953305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/f2699f876d6b/fendo-13-953305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/31e0de3a83e0/fendo-13-953305-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/cea51194956c/fendo-13-953305-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/7d2306c41868/fendo-13-953305-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/82e3e778989e/fendo-13-953305-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/8a9e6e0a448c/fendo-13-953305-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/1d705f02fa42/fendo-13-953305-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/f2699f876d6b/fendo-13-953305-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/31e0de3a83e0/fendo-13-953305-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/cea51194956c/fendo-13-953305-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9265/9433877/7d2306c41868/fendo-13-953305-g007.jpg

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