Dinda Biswanath, Dinda Manikarna, Dinda Subhajit, Chakraborty Mithun
Department of Chemistry, Tripura University, Suryamaninagar, Agartala, 799022, Tripura, India.
Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, 1300 Jefferson Park Ave, Va, 22908, USA.
Eur J Med Chem Rep. 2022 Dec;6:100079. doi: 10.1016/j.ejmcr.2022.100079. Epub 2022 Aug 28.
Currently an emerging human pathogenic coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused coronavirus disease 2019 (COVID-19) that has posed a serious threat to public health worldwide. As it is a novel severe pneumonia-type viral disease, no effective therapeutic agents are available to treat this infection to date, emphasizing an urgent need for development of effective anti-SARS-CoV-2 agents. Based on screening in computational biology and biological in vitro assays, a good number of natural compounds and their synthetic analogues have been confirmed to possess target-specific inhibitory effects against the activity of host and viral proteases, namely, cathepsin-L, TMPRSS2, Sec61, Mpro (3CL-protease), RNA-dependent RNA protease (RdRp), helicase cap-binding proteases eEF1A, eIF4A, eIF4E, which play dominant roles in progression of infection and replication of SARS-CoV-2 virus in host cells. This review paper describes the potent antiviral activity and target-specific anti-proteases activity of some natural compounds and their synthetic analogues against SARS-CoV-2 infection. It will inspire the researchers to unleash their own creativity and to design potent and safe drugs to fight the current COVID-19 pandemic.
目前，一种新出现的人类致病性冠状病毒，即严重急性呼吸综合征冠状病毒2（SARS-CoV-2），引发了2019冠状病毒病（COVID-19），对全球公共卫生构成了严重威胁。由于这是一种新型的严重肺炎型病毒性疾病，迄今为止尚无有效的治疗药物来治疗这种感染，这凸显了迫切需要开发有效的抗SARS-CoV-2药物。基于计算生物学筛选和体外生物学试验，大量天然化合物及其合成类似物已被证实对宿主和病毒蛋白酶的活性具有靶向特异性抑制作用，这些蛋白酶包括组织蛋白酶-L、跨膜丝氨酸蛋白酶2（TMPRSS2）、信号识别颗粒受体（Sec61）、M蛋白酶（3C样蛋白酶）、RNA依赖性RNA蛋白酶（RdRp）、解旋酶帽结合蛋白酶真核生物延伸因子1A（eEF1A）、真核生物翻译起始因子4A（eIF4A）、真核生物翻译起始因子4E（eIF4E），它们在SARS-CoV-2病毒在宿主细胞中的感染和复制进程中起主导作用。本文综述了一些天然化合物及其合成类似物对SARS-CoV-2感染的强效抗病毒活性和靶向特异性抗蛋白酶活性。它将激励研究人员发挥自己的创造力，设计出强效且安全的药物来对抗当前的COVID-19大流行。
