Department of Gynecologic Oncology, The First Affiliated Hospital of Henan Polytechnic University (The Second People's Hospital of Jiaozuo), No. 17 Minzhu South Road, Liberated Area, Jiaozuo, Henan 454000, China.
Dis Markers. 2022 Aug 26;2022:9697629. doi: 10.1155/2022/9697629. eCollection 2022.
The incidence of cervical cancer is increasing year by year, which seriously threatens the health of female patients. This study is aimed at investigating the association of sentinel lymph node biopsy (SLNB) with clinicopathological features in cervical cancer patients.
Patients diagnosed with cervical cancer in our hospital from February 1, 2019, to June 30, 2021, were selected as the research subjects. Statistical analysis was performed on the SLN examination of patients with cervical cancer with different pathological characteristics and the correlation between the positive rate of SLN detection and the pathological characteristics of cervical cancer.
A total of 59 patients with cervical cancer were included in this study, the SLNB detection rate was 94.92%, 15 patients had lymph node metastasis, and the metastasis rate was 25.42% confirmed by histopathology. Thirteen of them had SLN metastases, and the other 2 had non-SLN metastases. The sensitivity of SLNB was 86.67%, and the false negative rate was 13.33%. Statistical analysis results showed that there was no significant difference in the positive rate of SLN among cervical cancer patients with different FIGO stages, pathological types, degree of differentiation, depth of invasion, and tumor size. In addition, the results of Pearson's correlation analysis showed that the positive rate of SLN was not significantly correlated with the FIGO stage, pathological type, degree of differentiation, depth of invasion, and tumor size of cervical cancer.
SLNB has a high sensitivity, safety, and feasibility in the diagnosis and evaluation of lymph node metastasis in cervical cancer. There is no significant correlation between SLNB and the clinicopathological features of cervical cancer.
宫颈癌的发病率逐年上升，严重威胁女性患者的健康。本研究旨在探讨前哨淋巴结活检（SLNB）与宫颈癌患者临床病理特征的关系。
选取 2019 年 2 月 1 日至 2021 年 6 月 30 日在我院诊断为宫颈癌的患者为研究对象，对不同病理特征的宫颈癌患者 SLN 检查进行统计学分析，并分析 SLN 检测阳性率与宫颈癌病理特征的相关性。
本研究共纳入 59 例宫颈癌患者，SLNB 检测率为 94.92%，15 例患者经组织病理学证实存在淋巴结转移，转移率为 25.42%。其中 13 例 SLN 转移，另 2 例存在非 SLN 转移。SLNB 的灵敏度为 86.67%，假阴性率为 13.33%。统计分析结果显示，FIGO 分期、病理类型、分化程度、浸润深度、肿瘤大小不同的宫颈癌患者 SLN 阳性率无显著差异。此外，Pearson 相关性分析结果显示，SLN 阳性率与宫颈癌的 FIGO 分期、病理类型、分化程度、浸润深度和肿瘤大小无显著相关性。
SLNB 对宫颈癌淋巴结转移的诊断和评估具有较高的灵敏度、安全性和可行性，与宫颈癌的临床病理特征无显著相关性。
