Takanami I, Ikeda Y, Nakayama H
Gan To Kagaku Ryoho. 1987 Jul;14(7):2276-9.
Costus root oil is a new primary sensitizer for examination of the delayed cell-mediated immune system. Histologic findings of skin producing a positive reaction to costus root oil show accumulation of lymphoid cells. If the delayed hypersensitivity reaction caused by costus root oil were to be used as a means of aggregating lymphoid cells, these cells would attack cancer cells in a non-specific manner. In the present study, BALB/c mice were injected with 20% costus root oil. Fourteen days later, Meth-A tumor cells were transplanted subcutaneously, 3% costus root oil was injected around the transplanted tumor, and the effects on suppression of tumor growth were studied. The results indicated that the challenge of costus root oil had inhibited growth of the tumor in the sensitized group compared with the controls. It is anticipated that costus root oil will be quite promising as a non-specific agent for cancer immunotherapy.
闭鞘姜根油是用于检测迟发型细胞介导免疫系统的一种新型主要致敏剂。对闭鞘姜根油产生阳性反应的皮肤组织学检查结果显示有淋巴细胞聚集。如果将闭鞘姜根油引起的迟发型超敏反应用作聚集淋巴细胞的一种手段，这些细胞将以非特异性方式攻击癌细胞。在本研究中，给BALB/c小鼠注射20%的闭鞘姜根油。14天后，将Meth-A肿瘤细胞皮下移植，在移植肿瘤周围注射3%的闭鞘姜根油，并研究其对肿瘤生长抑制的作用。结果表明，与对照组相比，致敏组中闭鞘姜根油激发抑制了肿瘤生长。预计闭鞘姜根油作为一种非特异性癌症免疫治疗药物将非常有前景。
