Laboratory of Molecular Genetics and Biochemistry, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
Laboratory of Systems Biology, Institute of Biomedical Chemistry, Moscow, Russia.
PeerJ. 2022 Aug 30;10:e13907. doi: 10.7717/peerj.13907. eCollection 2022.
This article describes the most likely classes of proteins and molecular processes that specifically characterize schizophrenic spectrum disorders such as simple and paranoid schizophrenia, schizotypal disorder, and acute polymorphic psychotic disorder (APPD). The identification of patients' serum proteins was carried out using mass spectrometry. For patients with paranoid schizophrenia, the proteins responsible for translation and transcription are characteristic. A significant part of the proteins of patients with simple schizophrenia regulate the cell's main metabolic and transport processes. These are proteins of the receptor system, vesicular transport, and extracellular matrix, which mainly carry out catabolic processes. The proteins of patients with schizotypal disorder mostly coincided with the classes of other patients, apart from chaperone proteins, which were not found in other studied groups. These proteins are mainly involved in anabolic processes. The main classes of proteins found in patients with APPD are responsible for the metabolism of nucleic acids. Active apoptosis processes were also revealed in these patients. These results from our basic knowledge about the molecular mechanisms of the pathogenesis of these disorders.
本文描述了最有可能的蛋白质类别和分子过程，这些蛋白质类别和分子过程专门表征精神分裂症谱系障碍，如单纯型和偏执型精神分裂症、分裂型障碍和急性多形性精神病（APPD）。使用质谱法对患者的血清蛋白进行了鉴定。对于偏执型精神分裂症患者，负责翻译和转录的蛋白质是特征性的。单纯型精神分裂症患者的很大一部分蛋白质调节细胞的主要代谢和运输过程。这些是受体系统、囊泡运输和细胞外基质的蛋白质，主要进行分解代谢过程。分裂型障碍患者的蛋白质与其他患者的蛋白质类别大多重合，除了其他研究组中未发现的伴侣蛋白。这些蛋白质主要参与合成代谢过程。在 APPD 患者中发现的主要蛋白质类别负责核酸代谢。在这些患者中还发现了活跃的细胞凋亡过程。这些结果来自我们对这些疾病发病机制的分子机制的基本知识。
