免疫检查点疗法诱导的心肌炎和脑炎并发完全性房室传导阻滞：并非全无希望。
Checkpoint Immunotherapy-Induced Myocarditis and Encephalitis Complicated With Complete AV Block: Not All Hope Is Lost.
作者信息
Lorente-Ros Álvaro, Rajjoub-Al-Mahdi Ez-Alddin, Monteagudo Ruiz Juan M, Rivas García Sonia, Ortega Pérez Rodrigo, Fernández Golfín Covadonga, Álvarez-García Jesús, Zamorano Gómez José L
机构信息
Cardiology Department, Hospital Universitario Ramon y Cajal, Madrid, Spain.
Centro de Investigación Biomédica en Red, CIBER Cardiovascular, Madrid, Spain.
出版信息
JACC Case Rep. 2022 Aug 17;4(16):1032-1036. doi: 10.1016/j.jaccas.2022.04.020.
Immune checkpoint inhibitors are associated with a myriad of autoimmune adverse events. We present a 70-year-old patient with renal-cell carcinoma treated with nivolumab/ipilimumab complicated with myocarditis and encephalitis in which gradual impairment of the His-Purkinje system progressed to complete atrioventricular block. Full recovery was achieved after treatment with corticosteroids and immunoglobulins. ().
免疫检查点抑制剂与多种自身免疫性不良事件相关。我们报告一名70岁肾细胞癌患者，接受纳武单抗/伊匹单抗治疗后并发心肌炎和脑炎，希氏-浦肯野系统逐渐受损，进展为完全性房室传导阻滞。经皮质类固醇和免疫球蛋白治疗后完全康复。（）
Zotero 插件