Zhang Yan, Wu Danrong, Wang Ruoqiu, Luo Min, Wang Dong, Wang Kaiyue, Ai Yi, Zheng Li, Zhang Qiao, Shi Lixin
Department of Endocrinology and Metabolism, Guiqian International General Hospital, Guiyang, People's Republic of China.
Onco Targets Ther. 2022 Aug 29;15:913-918. doi: 10.2147/OTT.S378353. eCollection 2022.
Ectopic pituitary adenoma (EPA) is a pituitary adenoma unrelated to the intrasellar component and is an extremely rare disease. EPA resembles typical pituitary adenomas in morphology, immunohistochemistry, and hormonal activity, and it may present with specific or non-specific endocrine manifestations. Here, we report a rare case of ectopic adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma in the clival region. Only three patients with ACTH-secreting pituitary adenomas occurring in the clivus have been previously reported, and the present case was diagnosed as a clivus-ectopic ACTH-secreting pituitary macroadenoma. Thus, in addition to the more common organs, such as the lung, thymus, and pancreas, in the diagnosis of ectopic ACTH syndrome, special attention should be paid to the extremely rare ectopic ACTH-secreting pituitary adenoma of the clivus region.
异位垂体腺瘤（EPA）是一种与鞍内成分无关的垂体腺瘤，是一种极其罕见的疾病。EPA在形态学、免疫组织化学和激素活性方面类似于典型垂体腺瘤，可能表现为特异性或非特异性内分泌表现。在此，我们报告一例罕见的位于斜坡区的异位促肾上腺皮质激素（ACTH）分泌型垂体腺瘤。此前仅报道过3例发生于斜坡的ACTH分泌型垂体腺瘤，本病例被诊断为斜坡异位ACTH分泌型垂体大腺瘤。因此，在异位ACTH综合征的诊断中，除了肺、胸腺和胰腺等较常见的器官外，应特别注意斜坡区极其罕见的异位ACTH分泌型垂体腺瘤。
