Department of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Arch Clin Neuropsychol. 2023 Feb 18;38(2):276-282. doi: 10.1093/arclin/acac071.
To evaluate whether the Functional Activities Questionnaire (FAQ), a commonly used measure of functional status in neurodegenerative disease research, performs equivalently across demographically diverse subgroups of participants.
The FAQs from 30,613 National Alzheimer's Coordinating Center participants were evaluated with a hybrid graded response model-logistic ordinal regression approach to determine the presence of differential item functioning (DIF) within five demographic groups: education, ethnicity, race, language, and sex.
Measurable DIF was observed for FAQ items in all groups; however, measures of effect size, latent trait distributions, and item characteristic curves suggested that the impact was minimal for research and practice.
The FAQ is able to provide minimally biased assessments of daily functioning across diverse participants, suggesting potential value for offsetting disparities in diagnosis and treatment.
评估常用于神经退行性疾病研究的功能活动问卷（FAQ）在参与者的不同人口统计学亚组中是否具有等效性。
使用混合等级反应模型-逻辑有序回归方法评估了来自 30613 名国家阿尔茨海默病协调中心参与者的 FAQ，以确定五个人口统计学群体（教育程度、种族、民族、语言和性别）内是否存在差异项目功能（DIF）。
在所有群体中都观察到 FAQ 项目存在可衡量的 DIF；但是，效应大小、潜在特质分布和项目特征曲线的测量表明，这种影响在研究和实践中是微不足道的。
FAQ 能够为不同参与者提供最小偏差的日常功能评估，这表明它可能有助于抵消诊断和治疗方面的差异。
