University of Illinois at Chicago, Department of Medicine, Chicago, USA.
University of Pittsburgh, Department of Medicine, Pittsburgh, USA.
J Int Neuropsychol Soc. 2023 Jun;29(5):472-479. doi: 10.1017/S1355617722000406. Epub 2022 Sep 5.
The purpose of this exploratory study was to describe associations between NIH Toolbox-Cognition Battery subtests and legacy measures of neurocognitive function in two samples with neurological conditions (stroke and sickle cell disease (SCD)).
This exploratory secondary analysis uses data from two studies that assessed cognition at one time point using the NIH Toolbox-Cognition Battery, the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and subtests from the Delis-Kaplan Executive Functions System (DKEFS). People with stroke ( = 26) and SCD ( = 64) were included. Associations between the NIH Toolbox-Cognition Battery subtests and corresponding legacy measures were examined using linear correlations, Bland-Altman analysis, and Lin's Concordance Correlation Coefficient.
Linear correlations and Lin's Concordance Correlation Coefficient were poor to strong in both samples on NIH Toolbox-CB subtests: Flanker Inhibitory Control and Attention ( = .35 to .48, Lin CCC = .27 to .37), Pattern Comparison Processing Speed ( = .40 to .65, Lin CCC = .37 to .62), Picture Sequence Memory ( = .19 to .55, Lin CCC = .18 to .48), Dimensional Change Card Sort ( = .39 to .77, Lin CCC = .38 to .63), Fluid Cognition Composite ( = .88 to .90, Lin CCC = .60 to .79), and Total Cognition Composite ( = .64 to .83, Lin CCC = .60 to .78). Bland-Altman analyses demonstrated wide limits of agreement across all subtests (-3.17 to 3.78).
The NIH Toolbox-Cognition Battery subtests may behave similarly to legacy measures as an overall assessment of cognition across samples at risk for neurological impairment. Findings should be replicated across additional clinical samples.
本探索性研究旨在描述 NIH 工具包认知电池测验与两种神经疾病（中风和镰状细胞病（SCD））样本中传统神经认知功能测量之间的关联。
本探索性二次分析使用了两项研究的数据，这些研究在一个时间点使用 NIH 工具包认知电池、重复性认知评估量表（RBANS）和 Delis-Kaplan 执行功能系统（DKEFS）的测验来评估认知。纳入了中风患者（n=26）和 SCD 患者（n=64）。使用线性相关、Bland-Altman 分析和 Lin 的一致性相关系数来检查 NIH 工具包认知电池测验与相应传统测量之间的关联。
在两个样本中，NIH 工具包 CB 测验的 Flanker 抑制控制和注意力（r=.35 至.48，Lin CCC=.27 至.37）、模式比较处理速度（r=.40 至.65，Lin CCC=.37 至.62）、图片序列记忆（r=.19 至.55，Lin CCC=.18 至.48）、维度变化卡片分类（r=.39 至.77，Lin CCC=.38 至.63）、流体认知综合评分（r=.88 至.90，Lin CCC=.60 至.79）和总认知综合评分（r=.64 至.83，Lin CCC=.60 至.78）之间的线性相关性和 Lin 的一致性相关系数较差到强。Bland-Altman 分析表明，所有测验的一致性范围都很宽（-3.17 至 3.78）。
NIH 工具包认知电池测验可能与传统测量一样，作为神经损伤风险样本的认知整体评估。研究结果应在其他临床样本中得到复制。
