Omidi Negar, Khorgami Mohammadrafie, Khatami Farnaz, Mahalleh Mehrdad
Cardiac Primary Prevention Research Center, Cardiovascular Disease Research Institute, Tehran Heart Center (THC), Tehran University of Medical Sciences, Tehran, Iran.
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Rev Port Cardiol. 2022 Jan;41(1):43-47. doi: 10.1016/j.repc.2021.02.018. Epub 2021 Dec 24.
Pregnancy can affect the cardiac conduction system, causing changes to the electrocardiographic indices that may mimic pathologic ones. The aim of this study was to discover these changes in normal pregnant women.
We included 103 healthy pregnant women, aged between 18-35 years. Standard 12-lead electrocardiogram was performed in the first and third trimester and electrocardiographic indices were calculated. The patients were classified in two age categories.
The mean PR interval in trimester one (T1) was 133.36±20.9 ms and in third trimester (T3) was 125.03±22.6ms (p=0.046). The mean QT in T1 and T3 was 314.21±18.99 ms and 324.02±19.4 ms, respectively (p<0.001). QRS duration in T1 and T3 was 90.24±28.91 ms and 94.97±10.79 ms, respectively (p=0.027). Mean of QTc (corrected QT interval) was 384.03±23.2 in T1 and 393.20±42.48 ms in T3 (p 0.023). The difference in electrocardiogram indices between T1 and T3 was not significant within the two age groups.
When comparing results between T1 and T3, mean parameters of electrocardiogram indices showed significant statistical differences. This will contribute insight on the approach to a number of pregnant women who complain of palpitations and visit a cardiologist. Although not statistically significant, the QT dispersion was 2% higher in participants over 30 years of age.
妊娠可影响心脏传导系统，导致心电图指标发生变化，这些变化可能类似于病理性变化。本研究的目的是发现正常孕妇的这些变化。
我们纳入了103名年龄在18至35岁之间的健康孕妇。在孕早期和孕晚期进行标准12导联心电图检查，并计算心电图指标。将患者分为两个年龄组。
孕早期（T1）的平均PR间期为133.36±20.9毫秒，孕晚期（T3）为125.03±22.6毫秒（p = 0.046）。T1和T3的平均QT分别为314.21±18.99毫秒和324.02±19.4毫秒（p<0.001）。T1和T3的QRS时限分别为90.24±28.91毫秒和94.97±10.79毫秒（p = 0.027）。T1时QTc（校正QT间期）的平均值为384.03±23.2，T3时为393.20±42.48毫秒（p = 0.023）。两个年龄组中T1和T3之间的心电图指标差异不显著。
比较T1和T3的结果时，心电图指标的平均参数显示出显著的统计学差异。这将有助于深入了解一些主诉心悸并就诊于心脏病专家的孕妇的处理方法。尽管无统计学意义，但30岁以上参与者的QT离散度高2%。
