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用于载运和递送类胡萝卜素的脂质-生物大分子化合物的构建:制备方法、结构特性和吸收增强机制。

Construction of lipid-biomacromolecular compounds for loading and delivery of carotenoids: Preparation methods, structural properties, and absorption-enhancing mechanisms.

机构信息

College of Ocean Food and Biological Engineering, Jimei University, Xiamen, Fujian, People's Republic of China.

Collaborative Innovation Center of Provincial and Ministerial Co-construction for Marine Food Deep Processing, Dalian Polytechnic University, Dalian, China.

出版信息

Crit Rev Food Sci Nutr. 2024;64(6):1653-1676. doi: 10.1080/10408398.2022.2118229. Epub 2022 Sep 5.

DOI:10.1080/10408398.2022.2118229
PMID:36062817
Abstract

Due to the unstable chemical properties and poor water solubility of carotenoids, their processing adaptation and oral bioavailability are poor, limiting their application in hydrophilic food systems. Lipid-biomacromolecular compounds can be excellent carriers for carotenoid delivery by taking full advantage of the solubilization of lipids to non-polar nutrients and the water dispersion and gastrointestinal controlled release properties of biomacromolecules. This paper reviewed the research progress of lipid-biomacromolecular compounds as encapsulation and delivery carriers of carotenoids and summarized the material selection and preparation methods for biomacromolecular compounds. By considering the interaction between the two, this paper briefly discussed the effect of these compounds on carotenoid water solubility, stability, and bioavailability, emphasizing their delivery effect on carotenoids. Finally, various challenges and future trends of lipid-biomacromolecular compounds as carotenoid delivery carriers were discussed, providing new insight into efficient loading and delivery of carotenoids.

摘要

由于类胡萝卜素化学性质不稳定,水溶性差,其加工适应性和口服生物利用度较差,限制了其在亲水性食品体系中的应用。脂质-生物大分子化合物可以通过充分利用脂质对非极性营养素的溶解作用以及生物大分子的水分散性和胃肠道控制释放特性,成为类胡萝卜素传递的优良载体。本文综述了脂质-生物大分子化合物作为类胡萝卜素包封和传递载体的研究进展,并总结了生物大分子化合物的材料选择和制备方法。通过考虑两者之间的相互作用,本文简要讨论了这些化合物对类胡萝卜素水溶性、稳定性和生物利用度的影响,强调了它们对类胡萝卜素的传递效果。最后,讨论了脂质-生物大分子化合物作为类胡萝卜素传递载体的各种挑战和未来趋势,为类胡萝卜素的高效负载和传递提供了新的思路。

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