Department of Neuroscience, City University of Hong Kong, Kowloon, Hong Kong SAR.
Department of Nano-Bioengineering, Incheon National University, Incheon, South Korea.
J Cell Physiol. 2022 Nov;237(11):4037-4048. doi: 10.1002/jcp.30868. Epub 2022 Sep 5.
The hippocampus is regarded as a cognition hub, particularly for learning and memory. Previously, neuronal mechanisms underlying various cognitive functions are delineated with the lamellar hippocampal circuitry, dentate gyrus-CA3 or CA2-CA1, within the transverse plane. More recently, interlamellar (often referred to as longitudinal) projections have received intensive attention to help understand signal convergence and divergence in cognition and behavior. Signal propagation along the longitudinal axis is evidenced by axonal arborization patterns and synaptic responses to electro- and photo-stimulation, further demonstrating that information flow is more enriched in the longitudinal plane than the transverse plane. Here, we review the significance of longitudinal connections for cognition, discuss a putative circuit mechanism of place coding, and suggest the reconceptualization of the hippocampal circuitry.
海马体被认为是认知中枢，特别是在学习和记忆方面。以前，通过横向平面内的层状海马回路、齿状回-CA3 或 CA2-CA1，已经阐明了各种认知功能的神经元机制。最近，层间（通常称为纵向）投射受到了广泛关注，以帮助理解认知和行为中的信号汇聚和发散。沿着纵轴的信号传播由轴突分支模式和电刺激及光刺激的突触反应证明，进一步表明信息在纵轴上的流动比在横轴上更加丰富。在这里，我们回顾了纵向连接对认知的意义，讨论了位置编码的假设电路机制，并提出了海马电路的新概念化。
