Yang Sunggu, Chung Jaeyong, Jin Sung Hun, Bao Shaowen, Yang Sungchil
Department of Nano-bioengineering, Incheon National University, Incheon, 22012, South Korea.
Department of Electronics Engineering, Incheon National University, Incheon, 22012, South Korea.
Hear Res. 2018 Sep;366:32-37. doi: 10.1016/j.heares.2018.05.008. Epub 2018 May 17.
Sensory information in a temporal sequence is processed as a collective unit by the nervous system. The cellular mechanisms underlying how sequential inputs are incorporated into the brain has emerged as an important subject in neuroscience. Here, we hypothesize that information-bearing (IB) signals can be entrained and amplified by a clock signal, allowing them to efficiently propagate along in a feedforward circuit. IB signals can remain latent on individual dendrites of the receiving neurons until they are read out by an oscillatory clock signal. In such a way, the IB signals pass through the next neurons along a linear chain. This hypothesis identifies a cellular process of time-to-space and sound-to-map conversion in primary auditory cortex, providing insight into a mechanistic principle underlying the representation and memory of temporal sequences of information.
神经系统将按时间顺序排列的感觉信息作为一个整体单元进行处理。关于连续输入如何被纳入大脑的细胞机制已成为神经科学中的一个重要课题。在此，我们假设携带信息（IB）的信号可以被时钟信号夹带并放大，从而使其能够在前馈回路中高效地向前传播。IB信号可以潜伏在接收神经元的单个树突上，直到被振荡时钟信号读出。通过这种方式，IB信号沿着线性链传递到下一个神经元。这一假设确定了初级听觉皮层中时间到空间以及声音到图谱转换的细胞过程，为信息时间序列的表征和记忆背后的机制原理提供了见解。
