Department of Pharmacy, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Department of Clinical Laboratory, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Ecotoxicol Environ Saf. 2022 Oct 1;244:114041. doi: 10.1016/j.ecoenv.2022.114041. Epub 2022 Sep 2.
The abuse of antibiotics in animal husbandry has brought many public health problems, among which the passive use of antibiotics caused by eating food containing residual antibiotics has attracted the most attention. However, few studies have examined the possible adverse effects of prenatal antibiotics exposure on fetal growth and development. In this study, we investigated the associations between prenatal antibiotics exposure and measures of fetal growth. A total of 429 mother-newborn pairs from a birth cohort were enrolled and spot urine samples (N = 1287) were collected during each trimester of pregnancy. Sixteen antibiotics from 7 categories, were selected for the determination of the targeted antibiotics in maternal urines by UHPLC-MS/MS. Fetal growth indicators including newborn birth weight, birth length and gestational age (GA), were obtained from medical record. Sixteen antibiotics were found in 92.3% of the urine samples with detection frequencies ranging from 0.3% to 41.3%. Among the 16 antibiotics detected, we found that the exposure level of ciprofloxacin in the first trimester of pregnancy was negatively correlated with GA (β = -0.17 day, 95% CI, -0.32 to -0.02 day), which would increase the risk of preterm birth (OR=1.05, 95% CI, 1.00, 1.09). The exposure level of norfloxacin in the second trimester of pregnancy was negatively correlated with fetal birth weight (β = -17.56 g, 95% CI, -31.13 to -3.99 g) and birth length (β = -0.05 cm, 95% CI, -0.08 to -0.02 cm), and the exposure level of sulfamethoxazole in the third trimester of pregnancy was negatively correlated with fetal birth length (β = -0.15 cm, 95% CI, -0.29 to -0.02 cm). Our findings suggest that prenatal exposure to norfloxacin and sulfamethoxazole may adversely affect fetal growth and development.
畜牧业中抗生素的滥用带来了许多公共卫生问题，其中因食用含有残留抗生素的食物而被动使用抗生素引起了最多关注。然而，很少有研究探讨产前接触抗生素对胎儿生长和发育的可能不良影响。在这项研究中，我们调查了产前接触抗生素与胎儿生长指标之间的关系。共纳入了来自一个出生队列的 429 对母婴，并在每个孕期采集了点尿样（N=1287）。通过 UHPLC-MS/MS 选择了 7 类中的 16 种抗生素，用于检测母体尿液中的目标抗生素。从病历中获得了胎儿生长指标，包括新生儿出生体重、出生长度和胎龄（GA）。在 92.3%的尿液样本中发现了 16 种抗生素，检测频率从 0.3%到 41.3%不等。在所检测的 16 种抗生素中，我们发现妊娠早期环丙沙星的暴露水平与 GA 呈负相关（β=-0.17 天，95%CI：-0.32 至-0.02 天），这会增加早产的风险（OR=1.05，95%CI：1.00，1.09）。妊娠中期诺氟沙星的暴露水平与胎儿出生体重（β=-17.56 克，95%CI：-31.13 至-3.99 克）和出生长度（β=-0.05 厘米，95%CI：-0.08 至-0.02 厘米）呈负相关，妊娠晚期磺胺甲恶唑的暴露水平与胎儿出生长度（β=-0.15 厘米，95%CI：-0.29 至-0.02 厘米）呈负相关。我们的研究结果表明，产前接触诺氟沙星和磺胺甲恶唑可能会对胎儿生长和发育产生不良影响。
