淋巴细胞相关免疫炎症生物标志物在检测吉兰 - 巴雷综合征早期病情进展中的作用

Role of lymphocyte-related immune-inflammatory biomarkers in detecting early progression of Guillain-Barré syndrome.

作者信息

Xu Lu, Gao Tian-Xiao, Chang Sheng-Hui, Jiang Shu-Min, Zhang Lin-Jie, Yang Li

机构信息

Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.

出版信息

J Clin Neurosci. 2022 Nov;105:31-36. doi: 10.1016/j.jocn.2022.08.017. Epub 2022 Sep 2.

DOI:10.1016/j.jocn.2022.08.017

PMID:36063751

Abstract

OBJECTIVES

This study aimed to investigate the role of peripheral neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), and platelet to lymphocyte ratio (PLR) in the progression and severity of the Guillain-Barré syndrome (GBS).

METHODS

47 GBS patients and 50 age and sex-matched healthy controls (HC) were retrospectively included. Demographic and clinical assessment data were reviewed and abstracted. NLR, MLR, and PLR were calculated based on the peripheral blood tests by reviewing clinical data. The relationship between the Hughes' score and NLR, MLR, PLR levels was investigated.

RESULTS

The GBS patients had higher NLR levels (P < 0.001), MLR levels (P = 0.001) and PLR levels (P < 0.001) than those in HC. And patients with severe disability score (Hughes' score ≥ 3) had significantly higher NLR (P = 0.007), MLR (P = 0.04), PLR (P = 0.013). Spearman correlation analysis indicated that NLR was positively associated with the Hughes' score (r = 0.331, P = 0.023). In the patients with acute inflammatory demyelinating polyneuropathy (AIDP), Spearman correlation analysis indicated that NLR, MLR and PLR were positively associated to the Hughes' score (r = 0.825, P = 0.001 for NLR, r = 0.727, P = 0.005 for MLR, and r = 0.723, P = 0.005 for PLR).

CONCLUSIONS

NLR, MLR, and PLR may be indicators of disease activity in patients with GBS or AIDP. These parameters may benefit the active treatment of GBS patients with a high degree of disability.

摘要

目的

本研究旨在探讨外周血中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）以及血小板与淋巴细胞比值（PLR）在吉兰 - 巴雷综合征（GBS）病情进展及严重程度中的作用。

方法

回顾性纳入47例GBS患者及50例年龄和性别匹配的健康对照（HC）。对人口统计学和临床评估数据进行回顾与提取。通过查阅临床资料，根据外周血检查计算NLR、MLR和PLR。研究休斯评分与NLR、MLR、PLR水平之间的关系。

结果

GBS患者的NLR水平（P < 0.001）、MLR水平（P = 0.001）和PLR水平（P < 0.001）均高于HC。重度残疾评分（休斯评分≥3）的患者NLR（P = 0.007）、MLR（P = 0.04）、PLR（P = 0.013）显著更高。Spearman相关性分析表明，NLR与休斯评分呈正相关（r = 0.331，P = 0.023）。在急性炎症性脱髓鞘性多发性神经病（AIDP）患者中，Spearman相关性分析表明，NLR、MLR和PLR与休斯评分呈正相关（NLR：r = 0.825，P = 0.001；MLR：r = 0.727，P = 0.005；PLR：r = 0.723，P = 0.005）。