Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China; Institute of Cerebrovascular Diseases, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao 266000, China.
Clin Neurol Neurosurg. 2023 Dec;235:108015. doi: 10.1016/j.clineuro.2023.108015. Epub 2023 Oct 17.
Systemic immune-inflammation index (SII) and platelet/neutrophil to lymphocyte ratio (P/NLR) are two novel hematological inflammatory indices, this study invested the role of SII and P/NLR in Guillain-Barré syndrome (GBS).
A total of 115 GBS patients and 120 healthy controls were enrolled in this retrospective study, SII and P/NLR were calculated from the value of complete blood counts. The Hughes Functional Grading Scale (HFGS) score on admission and at discharge was used to evaluate the severity and short-term outcome of GBS. The level of SII and P/NLR was compared between GBS patients and healthy controls, and the correlation between SII, P/NLR, and GBS's severity as well as poor short-term outcome was analyzed.
Increased SII (p < 0.001) and decreased P/NLR (p < 0.001) were observed in patients with GBS and the level of SII (p = 0.689) and P/NLR (p = 0.879) was not different between GBS subtypes. Patients with severe GBS and poor short-term outcomes had higher levels of SII and lower levels of P/NLR (p < 0.05), SII was positively correlated and P/NLR was negatively correlated with the HFGS score on admission and at discharge (p < 0.05). To predict severe GBS, the optimal cutoff value of SII was 620.87 (AUC0.633, sensitivity 60.8 % and specificity 60.9 %, p = 0.014), the optimal cutoff value of P/NLR was 53.11 (AUC0.635, sensitivity 45.1 %, specificity 82.8 %, p = 0.013). The SII level of 620.87 was found to be optimal predictive cutoff value for the poor short-term outcome of GBS (AUC 0.728, sensitivity of 82.6 %, specificity of 59.8 %, p = 0.001), the P/NLR level of 62.80 was found to be optimal predictive cutoff value for the poor short-term outcome of GBS (AUC 0.669, sensitivity 60.9 %, specificity 71.7 %, p = 0.012). Both SII>620.87 (p = 0.005) and P/NLR<53.11 (p = 0.002) were independent risk factors for severe GBS, and SII>620.87 (p = 0.035) was independently associated with the poor short-term outcome of GBS.
SII and P/NLR may be useful biomarkers to reflect GBS patients' severity and short-term outcome.
全身性免疫炎症指数（SII）和血小板/中性粒细胞与淋巴细胞比值（P/NLR）是两种新的血液学炎症指标，本研究探讨了 SII 和 P/NLR 在吉兰-巴雷综合征（GBS）中的作用。
本回顾性研究纳入了 115 例 GBS 患者和 120 例健康对照者，从全血细胞计数中计算 SII 和 P/NLR 值。入院时和出院时采用 Hughes 功能分级量表（HFGS）评分评估 GBS 的严重程度和短期预后。比较 GBS 患者和健康对照组之间 SII 和 P/NLR 的水平，并分析 SII、P/NLR 与 GBS 严重程度和不良短期预后的相关性。
GBS 患者的 SII（p<0.001）升高和 P/NLR（p<0.001）降低，GBS 各亚型之间 SII（p=0.689）和 P/NLR（p=0.879）水平无差异。严重 GBS 和不良短期预后的患者 SII 水平较高，P/NLR 水平较低（p<0.05），SII 与入院和出院时的 HFGS 评分呈正相关，而 P/NLR 与 HFGS 评分呈负相关（p<0.05）。预测严重 GBS 时，SII 的最佳截断值为 620.87（AUC0.633，敏感性 60.8%，特异性 60.9%，p=0.014），P/NLR 的最佳截断值为 53.11（AUC0.635，敏感性 45.1%，特异性 82.8%，p=0.013）。SII 水平为 620.87 时是预测 GBS 不良短期预后的最佳截断值（AUC 0.728，敏感性 82.6%，特异性 59.8%，p=0.001），P/NLR 水平为 62.80 时是预测 GBS 不良短期预后的最佳截断值（AUC 0.669，敏感性 60.9%，特异性 71.7%，p=0.012）。SII>620.87（p=0.005）和 P/NLR<53.11（p=0.002）均是严重 GBS 的独立危险因素，SII>620.87（p=0.035）与 GBS 的不良短期预后相关。
SII 和 P/NLR 可能是反映 GBS 患者严重程度和短期预后的有用生物标志物。
