肾脏疾病中能量代谢的重编程。
Reprogramming of Energy Metabolism in Kidney Disease.
机构信息
Division of Nephrology and Hypertension, University of California San Diego, San Diego, California, USA.
VA San Diego Healthcare System, San Diego, California, USA.
出版信息
Nephron. 2023;147(1):61-64. doi: 10.1159/000526308. Epub 2022 Sep 5.
Abstract
Kidney tubules have high metabolic activity to support solute transport and other cellular functions. Energy generation in the kidney is largely dependent on mitochondrial oxidative phosphorylation, particularly in the proximal tubules. Important alterations in the pathways of energy generation and cellular metabolism have been identified in early and late stages of kidney disease. This review provides a succinct summary of the current literature on the central role of energy metabolism in the pathophysiology of acute and chronic kidney disease.
摘要
肾小管具有较高的代谢活性，以支持溶质转运和其他细胞功能。肾脏中的能量产生主要依赖于线粒体氧化磷酸化，特别是在近端肾小管中。在肾脏病的早期和晚期阶段，已经确定了能量产生和细胞代谢途径的重要改变。这篇综述简要总结了目前关于能量代谢在急性和慢性肾脏病病理生理学中核心作用的文献。
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