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用于计算机断层扫描的蒽单晶闪烁体。

Anthracene Single-Crystal Scintillators for Computer Tomography Scanning.

作者信息

Chen Mingxi, Sun Lingjie, Hong Zhongzhu, Wang Hongyun, Xia Yan, Liu Si, Ren Xiaochen, Zhang Xiaotao, Chi Dongzhi, Yang Huanghao, Hu Wenping

机构信息

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Sciences, Tianjin University, Tianjin 300072, China.

Agency for Science, Technology and Research (A*STAR), Institute of Materials Research and Engineering, Innovis, 2 Fusionopolis Way, Singapore 138634, Singapore.

出版信息

ACS Appl Mater Interfaces. 2022 Sep 14;14(36):41275-41282. doi: 10.1021/acsami.2c09732. Epub 2022 Sep 5.

DOI:10.1021/acsami.2c09732
PMID:36064330
Abstract

X-ray imaging and computed tomography (CT) technology, as the important non-destructive measurements, can observe internal structures without destroying the detected sample, which are always used in biological diagnosis to detect tumors, pathologies, and bone damages. It is always a challenge to find materials with a low detection limit, a short exposure time, and high resolution to reduce X-ray damage and acquire high-contrast images. Here, we described a low-cost and high-efficient method to prepare centimeter-sized anthracene crystals, which exhibited intense X-ray radioluminescence with a detection limit of ∼0.108 μGy s, which is only one-fifth of the dose typically used for X-ray diagnostics. Additionally, the low absorption reduced the damage in radiation and ensured superior cycle performance. X-ray detectors based on anthracene crystals also exhibited an extremely high resolution of 40 lp mm. The CT scanning and reconstruction of a foam sample were then achieved, and the detailed internal structure could be clearly observed. These indicated that organic crystals are expecting to be leading candidate low-cost materials for low-dose and highly sensitive X-ray detection and CT scanning.

摘要

X射线成像和计算机断层扫描(CT)技术作为重要的无损测量手段,能够在不破坏被检测样本的情况下观察其内部结构,常用于生物诊断中检测肿瘤、病变和骨骼损伤。寻找具有低检测限、短曝光时间和高分辨率的材料以减少X射线损伤并获取高对比度图像一直是一项挑战。在此,我们描述了一种低成本、高效率的方法来制备厘米级的蒽晶体,该晶体表现出强烈的X射线辐射发光,检测限约为0.108μGy s,仅为X射线诊断通常使用剂量的五分之一。此外,低吸收减少了辐射损伤并确保了优异的循环性能。基于蒽晶体的X射线探测器还表现出40 lp mm的极高分辨率。然后实现了对泡沫样品的CT扫描和重建,能够清晰观察到详细的内部结构。这些表明有机晶体有望成为低剂量、高灵敏度X射线检测和CT扫描的低成本领先候选材料。

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