镰状细胞病患者输血的不良反应。
Adverse events of red blood cell transfusions in patients with sickle cell disease.
机构信息
Children's Healthcare of Atlanta, Department of Pathology and Laboratory Medicine, 1405 Clifton Rd NE, 1st Floor, Atlanta, GA 30322, USA; Emory University School of Medicine, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, 1405 Clifton Rd NE, Atlanta, GA 30322, USA.
The Children's Hospital of Philadelphia, Departments of Pediatrics and Pathology and Laboratory Medicine, The School of Medicine at the University of Pennsylvania, 3615 Civic Center Boulevard, Abramson Research Building Room 316D, Philadelphia, PA 19104, USA.
出版信息
Transfus Apher Sci. 2022 Oct;61(5):103557. doi: 10.1016/j.transci.2022.103557. Epub 2022 Aug 29.
Blood transfusion is a common medical intervention for patients with sickle cell disease (SCD) and disease related complications. While patients with SCD are at risk for all transfusion related adverse events defined by the National Healthcare Safety Network (NHSN) Biovigilance Component Hemovigilance Module Surveillance Protocol, they are uniquely susceptible to certain adverse events. This review discusses risk factors, mitigation strategies, and management recommendations for alloimmunization, hemolytic transfusion reactions, hyperviscosity and transfusion-associated iron overload in the context of SCD.
输血是镰状细胞病（SCD）患者和相关疾病并发症的常见医疗干预措施。尽管 SCD 患者面临着国家医疗保健安全网络（NHSN）生物监测组件血液监测模块监测方案定义的所有与输血相关的不良事件风险，但他们特别容易受到某些不良事件的影响。本文讨论了在 SCD 背景下同种免疫、溶血性输血反应、高粘滞血症和输血相关铁过载的危险因素、缓解策略和管理建议。
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