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[调强适形放疗用于直肠癌新辅助治疗的影响?]

[Impact of IMRT for neoadjuvant rectal cancer?].

作者信息

Pointreau Y, Moreau J, Vendrely V, Schipman B

机构信息

Institut interrégional de cancérologie (ILC) - centre Jean-Bernard, 9, rue Beauverger, 72000 Le Mans, France; Club des oncologues libéraux (Colib), Le Mans, France.

Département de radiothérapie, centre Jean-Perrin, 58, rue Montalembert, BP 5026, 63011 Clermont-Ferrand cedex 1, France.

出版信息

Cancer Radiother. 2022 Oct;26(6-7):865-870. doi: 10.1016/j.canrad.2022.06.001. Epub 2022 Sep 5.

Abstract

The standard management of locally advanced rectal tumors as cT3-T4 and/or N0/N1 is based on preoperative treatment combining radiotherapy of 45 to 50Gy and chemotherapy based on 5-fluorouracil. Intensity-modulated radiotherapy has already shown its interest compared to conformal radiotherapy in other locations, like in pelvic cancer. The role of intensity-modulated radiotherapy in the pre/postoperative treatment of rectal cancers is not a standard of care. Published studies showed its feasibility with the objective of less toxicity with equivalent efficacy.

摘要

局部晚期直肠肿瘤(cT3-T4和/或N0/N1)的标准管理基于术前治疗,联合45至50Gy的放疗以及基于5-氟尿嘧啶的化疗。与适形放疗相比,调强放疗已在其他部位(如盆腔癌)显示出其优势。调强放疗在直肠癌术前/术后治疗中的作用并非标准治疗方法。已发表的研究表明其具有可行性,目标是在疗效相当的情况下降低毒性。

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