AIP：双重角色？AIP 在组织特异性中作为抑癌基因或癌基因的作用。
AIP: A double agent? The tissue-specific role of AIP as a tumour suppressor or as an oncogene.
机构信息
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
School of Life Sciences, University of Westminster, London, W1W 6UW, UK.
出版信息
Br J Cancer. 2022 Oct;127(7):1175-1176. doi: 10.1038/s41416-022-01964-7. Epub 2022 Sep 5.
Aryl hydrocarbon receptor-interacting protein (AIP) is a co-chaperone to heat shock proteins and nuclear receptors. Loss-of-function heterozygote germline mutations lead to predisposition to growth hormone- or prolactin-secreting pituitary typically presenting in childhood. Based on these data AIP behaves as a tumour suppressor. However, previously in diffuse large B cell lymphoma and now in this new manuscript in the British Journal of Cancer on colorectal cancer, it seems that high expression of AIP is associated with tumour development and more aggressive disease. AIP, therefore, joins a distinguished group of proteins that can behave both as a tumour suppressor and as an oncogene.
芳烃受体相互作用蛋白 (AIP) 是热休克蛋白和核受体的共伴侣。失活杂合子种系突变导致生长激素或催乳素分泌性垂体瘤易感性，通常在儿童期发病。基于这些数据，AIP 表现为肿瘤抑制因子。然而，之前在弥漫性大 B 细胞淋巴瘤中，现在在《英国癌症杂志》关于结直肠癌的新论文中，AIP 的高表达似乎与肿瘤发展和更具侵袭性的疾病相关。因此，AIP 加入了一组表现为肿瘤抑制因子和癌基因的杰出蛋白质。
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