Leoni Luís Antônio B, Fukushima André R, Rocha Leandro Y, Maifrino Laura B M M, Rodrigues Bruno
Human Movement Laboratory, São Judas Tadeu University (USJT) , São Paulo , Brazil.
Aging Male. 2014 Sep;17(3):125-30. doi: 10.3109/13685538.2014.923836. Epub 2014 Jun 4.
Physical inactivity, diabetes, hypertension, dyslipidemia, smoking and obesity were associated with imbalance in oxidative stress, leading to endothelial dysfunction. Such dysfunction is present in both cardiovascular disease (CVD) and erectile dysfunction (ED). ED is the persistent inability to achieve or sustain an erection sufficient for satisfactory sexual performance and is one of the first manifestations of endothelial damage in men with CVD risk factors. The purpose of this article is to review the results of studies involving physical activity, CVD, endothelial dysfunction and ED in order to verify its applicability for improving the health and quality of life of men with such disorders. There is consistent evidence that endothelial damage is intimately linked to ED, and this manifestation seems to be associated with the appearance CVDs. On the other hand, physical activity has been pointed out as an important clinical strategy in the prevention and treatment of CVDs and ED mainly associated with improvement of endothelial function. However, further experimental and clinical prospective investigations are needed to test the role of physical exercises in the modulation of endothelial function and their implications on erectile function and the appearance of CVDs.
缺乏身体活动、糖尿病、高血压、血脂异常、吸烟和肥胖与氧化应激失衡相关，进而导致内皮功能障碍。这种功能障碍在心血管疾病（CVD）和勃起功能障碍（ED）中均存在。ED是指持续无法达到或维持足以实现满意性行为的勃起状态，并且是具有CVD危险因素的男性内皮损伤的首批表现之一。本文的目的是综述涉及身体活动、CVD、内皮功能障碍和ED的研究结果，以验证其对改善患有此类疾病男性的健康和生活质量的适用性。有一致的证据表明内皮损伤与ED密切相关，并且这种表现似乎与CVD的出现有关。另一方面，身体活动已被指出是预防和治疗CVD及ED的重要临床策略，主要与内皮功能的改善相关。然而，需要进一步的实验和临床前瞻性研究来测试体育锻炼在内皮功能调节中的作用及其对勃起功能和CVD出现的影响。
