Nutrition-Diabetology, CHU of Bordeaux, Haut-Lévêque Hospital, F-33600 Pessac, France.
University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR U1219, F-33000 Bordeaux, France.
Nutr Metab Cardiovasc Dis. 2022 Nov;32(11):2526-2533. doi: 10.1016/j.numecd.2022.08.009. Epub 2022 Aug 13.
Advanced glycation end products are involved in age-related multisystem decline. They accumulate in body tissues with age, diabetes and chronic kidney disease (CKD), and can be measured non-invasively by the skin autofluorescence (SAF). We studied the relation between SAF and later mortality in old adults.
The SAF was measured using an AGE-Reader in 451 individuals from the general population aged over 75 years, and all-cause mortality was assessed during an average follow-up of 6.4 years. The association between SAF and mortality was analyzed using a multivariate Cox survival model, adjusted for age and gender. Analyses were further adjusted for diabetes and stratified on the presence of CKD due to its interaction with SAF for the risk of mortality. Participants were 82 years old on average (SD 4.1). Their mean SAF was 2.8 AU (SD 0.6). One hundred and forty-four individuals (31.9%) died during the follow-up. Adjusted for age and gender, SAF was associated with an increased risk of all-cause mortality (HR 1.44, 95%CI: 1.14-1.82 for a one-AU increase of SAF). The association was no longer significant after adjustment for diabetes. However, after stratification for the presence of CKD, higher SAF was associated with an increased risk of all-cause mortality in the participants with CKD at baseline (HR 1.68, 95%CI: 1.11-2.55), whereas there was no association among participants without CKD (HR 0.95, 95%CI: 0.63-1.44).
Skin autofluorescence is associated with increased all-cause mortality in older adults already suffering from CKD.
晚期糖基化终产物（AGE）参与与年龄相关的多系统衰退。它们随着年龄的增长、糖尿病和慢性肾脏病（CKD）在体内组织中积累，并且可以通过皮肤自发荧光（SAF）进行非侵入性测量。我们研究了 SAF 与老年患者后期死亡率之间的关系。
在年龄超过 75 岁的普通人群中，有 451 人使用 AGE-Reader 测量了 SAF，在平均 6.4 年的随访期间评估了全因死亡率。使用多变量 Cox 生存模型分析了 SAF 与死亡率之间的关系，并根据年龄和性别进行了调整。由于 SAF 与 CKD 之间存在交互作用，因此进一步根据糖尿病进行了调整，并根据 CKD 的存在进行了分层，以分析 SAF 对死亡率的风险。参与者的平均年龄为 82 岁（标准差 4.1）。他们的平均 SAF 为 2.8 AU（标准差 0.6）。在随访期间，有 144 人（31.9%）死亡。根据年龄和性别进行调整后，SAF 与全因死亡率的风险增加相关（HR 1.44，95%CI：1.14-1.82，SAF 增加一个单位）。在调整了糖尿病后，这种关联不再显著。然而，在根据 CKD 的存在进行分层后，在基线时患有 CKD 的参与者中，较高的 SAF 与全因死亡率的风险增加相关（HR 1.68，95%CI：1.11-2.55），而在没有 CKD 的参与者中则没有相关性（HR 0.95，95%CI：0.63-1.44）。
皮肤自发荧光与已经患有 CKD 的老年患者全因死亡率的增加相关。
