Kdimy Ayoub, El Yadini Meryem, Guaadaoui Abdelkarim, Bourais Ilhame, El Hajjaji Souad, Le Hoang V
LS3MN2E, CERNE2D, Faculty of Science, Mohammed V University in Rabat, Rabat, 10056, Morocco.
Department of BioMolecular Sciences and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi, 38677, USA.
Chem Biodivers. 2022 Oct;19(10):e202200300. doi: 10.1002/cbdv.202200300. Epub 2022 Sep 23.
Capparis spinosa L., commonly known as the caper bush, is an aromatic plant growing in most of the Mediterranean basin and some parts of Western Asia. C. spinosa L. has been utilized as a medicinal plant for quite a long time in conventional phytomedicine. Polyphenols and numerous bioactive chemicals extracted from C. spinosa L. display various therapeutic properties that have made this plant a target for further research as a health promoter. This review is meant to systematically summarize the traditional uses, the phytochemical composition of C. spinosa L., and the diverse pharmacological activities, as well as the synthetic routes to derivatives of some identified chemical components for the improvement of biological activities and enhancement of pharmacokinetic profiles. This review also addresses the benefits of C. spinosa L. in adapting to climate change and the socio-economic value that C. spinosa L. brings to the rural economies of many countries.
刺山柑,通常被称为刺山柑灌木,是一种生长在地中海盆地大部分地区和西亚部分地区的芳香植物。在传统植物医学中,刺山柑长期以来一直被用作药用植物。从刺山柑中提取的多酚和许多生物活性化学物质具有多种治疗特性,这使得这种植物成为作为健康促进剂进行进一步研究的目标。本综述旨在系统地总结刺山柑的传统用途、植物化学成分、多样的药理活性,以及一些已鉴定化学成分的衍生物的合成路线,以改善生物活性和增强药代动力学特征。本综述还探讨了刺山柑在适应气候变化方面的益处以及刺山柑给许多国家农村经济带来的社会经济价值。