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polysaccharide induces the metabolic shifts and gut microbiota change of lung cancer in mice.

作者信息

Lu Yingfang, Peng Bo, Lin Yuqi, Lin Qianmin, Xia Xuewei, Zhong Saiyi, Luo Lianxiang, Huang Riming

机构信息

Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China.

State Key Laboratory of Organic Geochemistry, Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China, CAS Center for Excellence in Deep Earth Science, Guangzhou, 510640, China.

出版信息

Curr Res Food Sci. 2022 Aug 24;5:1313-1319. doi: 10.1016/j.crfs.2022.08.010. eCollection 2022.

DOI:10.1016/j.crfs.2022.08.010
PMID:36065196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9440268/
Abstract

A polysaccharide obtained from (PSP) and its effect on lung cancer in mice was investigated. Our results indicate that the tumor volume and weight of the lung cancer-bearing mice treated with PSP decreased significantly. Metabolite analysis showed that 27 differential accumulated metabolites (DAMs) changed significantly, in which 24 DAMs increased while 3 DAMs decreased. KEGG enrichment results showed that these differential metabolites were enriched significantly in the high-affinity IgE receptor (FcεRI) signaling pathway and arachidonic acid metabolism. In addition, PSP modulated gut microbiota of the lung cancer-bearing mice. PSP increased the abundance of , , , and , decreasing and . The results might be related to suppressing lung cancer. Based on our study, we hypothesized that PSP inhibited lung cancer through FcεRI signaling pathway and arachidonic acid metabolism and regulated the balance of gut microbiota. Nevertheless, the relationship between these two pathways and gut microbiota needs further study.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbb/9440268/5b1ecab9aff3/gr4a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbb/9440268/c77fd4e74ab3/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbb/9440268/b3cfc3ef2f40/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbb/9440268/c92dc87f20a0/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbb/9440268/ac478a2073e6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbb/9440268/5b1ecab9aff3/gr4a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbb/9440268/c77fd4e74ab3/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbb/9440268/b3cfc3ef2f40/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbb/9440268/c92dc87f20a0/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbb/9440268/ac478a2073e6/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fbb/9440268/5b1ecab9aff3/gr4a.jpg

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polysaccharide induces the metabolic shifts and gut microbiota change of lung cancer in mice.

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引用本文的文献

[1]
Potential associations between gut and skin microbiota and lung cancer: a bidirectional Mendelian randomization analysis.

Discov Oncol. 2025-5-24

[2]
Effects of Natural Polysaccharides on the Gut Microbiota Related to Human Metabolic Health.

Mol Nutr Food Res. 2025-6

[3]
Prediction of lung adenocarcinoma prognosis and diagnosis with a novel model anchored in circadian clock-related genes.

Sci Rep. 2024-8-6

[4]
Global research trends between gut microbiota and lung cancer from 2011 to 2022: A bibliometric and visualization analysis.

Front Oncol. 2023-2-23

本文引用的文献

[1]
Top advances in lung cancer, 2021.

Cancer. 2022-10-1

[2]
Polysaccharide from Evokes Antitumor Activity in Gastric Cancer Cells Modulation of Galectin-3 and Exhibited Cyto/DNA Protection: Structure-Function Study.

J Agric Food Chem. 2022-6-15

[3]
Structural characterization, and in vitro immunostimulatory and antitumor activity of an acid polysaccharide from Spirulina platensis.

Int J Biol Macromol. 2022-1-31

[4]
Immunomodulatory sulfated polysaccharides from Caulerpa racemosa var. peltata induces metabolic shifts in NF-κB signaling pathway in RAW 264.7 macrophages.

Int J Biol Macromol. 2021-7-1

[5]
Gallstone Disease, Obesity and the Firmicutes/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis.

J Pers Med. 2020-12-25

[6]
Structural characterization and transcript-metabolite correlation network of immunostimulatory effects of sulfated polysaccharides from green alga Ulva pertusa.

Food Chem. 2021-4-16

[7]
Leukotrienes in Tumor-Associated Inflammation.

Front Pharmacol. 2020-8-19

[8]
Novel airway smooth muscle-mast cell interactions and a role for the TRPV4-ATP axis in non-atopic asthma.

Eur Respir J. 2020-7

[9]
Structural Features of Three Hetero-Galacturonans from Fruits and Their in Vitro Immunomodulatory Effects.

Polymers (Basel). 2020-3-8

[10]
Production of a novel α-amylase by Bacillus atrophaeus NRC1 isolated from honey: Purification and characterization.

Int J Biol Macromol. 2020-1-13

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