多糖诱导小鼠肺癌的代谢转变和肠道微生物群变化。
polysaccharide induces the metabolic shifts and gut microbiota change of lung cancer in mice.
作者信息
Lu Yingfang, Peng Bo, Lin Yuqi, Lin Qianmin, Xia Xuewei, Zhong Saiyi, Luo Lianxiang, Huang Riming
机构信息
Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University, Guangzhou, 510642, China.
State Key Laboratory of Organic Geochemistry, Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China, CAS Center for Excellence in Deep Earth Science, Guangzhou, 510640, China.
出版信息
Curr Res Food Sci. 2022 Aug 24;5:1313-1319. doi: 10.1016/j.crfs.2022.08.010. eCollection 2022.
A polysaccharide obtained from (PSP) and its effect on lung cancer in mice was investigated. Our results indicate that the tumor volume and weight of the lung cancer-bearing mice treated with PSP decreased significantly. Metabolite analysis showed that 27 differential accumulated metabolites (DAMs) changed significantly, in which 24 DAMs increased while 3 DAMs decreased. KEGG enrichment results showed that these differential metabolites were enriched significantly in the high-affinity IgE receptor (FcεRI) signaling pathway and arachidonic acid metabolism. In addition, PSP modulated gut microbiota of the lung cancer-bearing mice. PSP increased the abundance of , , , and , decreasing and . The results might be related to suppressing lung cancer. Based on our study, we hypothesized that PSP inhibited lung cancer through FcεRI signaling pathway and arachidonic acid metabolism and regulated the balance of gut microbiota. Nevertheless, the relationship between these two pathways and gut microbiota needs further study.
研究了从[具体来源未提及]获得的一种多糖（PSP）及其对小鼠肺癌的影响。我们的结果表明，用PSP治疗的荷肺癌小鼠的肿瘤体积和重量显著降低。代谢物分析表明，27种差异积累代谢物（DAMs）发生了显著变化，其中24种DAMs增加而3种DAMs减少。KEGG富集结果表明，这些差异代谢物在高亲和力IgE受体（FcεRI）信号通路和花生四烯酸代谢中显著富集。此外，PSP调节了荷肺癌小鼠的肠道微生物群。PSP增加了[具体微生物名称1]、[具体微生物名称2]、[具体微生物名称3]和[具体微生物名称4]的丰度，降低了[具体微生物名称5]和[具体微生物名称6]的丰度。这些结果可能与抑制肺癌有关。基于我们的研究，我们假设PSP通过FcεRI信号通路和花生四烯酸代谢抑制肺癌，并调节肠道微生物群的平衡。然而，这两条通路与肠道微生物群之间的关系需要进一步研究。
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