Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Division of Biostatistics, Medical Excellence Inc., Seoul, Korea.
Endocrinol Metab (Seoul). 2022 Aug;37(4):664-673. doi: 10.3803/EnM.2022.1499. Epub 2022 Aug 29.
Patients with thyroid cancer undergo less extensive surgery and additional therapies compared to those with other cancers. We aimed to compare the quality of life (QoL) between patients with thyroid cancer and healthy subjects using representative data from Korea. Differences in QoL of thyroid cancer survivors according to the duration after cancer diagnosis was also evaluated.
This population-based cohort study included 50,278 subjects who participated in the Korea National Health and Nutrition Examination Survey between 2007 and 2017. QoL was compared between patients with thyroid cancer and healthy subjects using self-reported data from the EuroQoL (EQ)-5 dimension (5D) and EQ-visual analog scale (VAS). Propensity score matching was used to match thyroid cancer survivors to healthy subjects (1:5 matching).
Linear regression with univariate analysis showed that the presence of thyroid cancer was positively correlated with better EQ-5D index scores (β-coefficient=0.010, p=0.046). After adjusting for multiple covariables, statistical significance was maintained. EQ-VAS fails to demonstrate any significant correlation. Among the EQ-5D categories, patients with thyroid cancer showed better self-care than healthy subjects. Thyroid cancer duration did not correlate with the EQ-5D index score. In subgroup analyses, compared to patients with thyroid cancer duration of <5 years, no significant difference was observed in the correlation between the EQ-5D index score and survival duration in those with thyroid cancer duration of 5 to 9 years and ≥10 years.
Using a large-scale nationwide population-based database, our study demonstrated better QoL, especially in terms of self-care, among thyroid cancer survivors than among healthy subjects without cancer.
与其他癌症患者相比，甲状腺癌患者的手术范围较小，接受的治疗也较少。我们旨在利用来自韩国的代表性数据，比较甲状腺癌患者和健康受试者的生活质量（QoL）。此外，还评估了甲状腺癌幸存者在癌症诊断后不同时间段 QoL 的差异。
本基于人群的队列研究纳入了 50278 名 2007 年至 2017 年期间参加韩国国家健康和营养检查调查的受试者。使用来自欧洲生命质量五维量表（EQ-5D）和 EQ 视觉模拟量表（VAS）的自我报告数据，比较甲状腺癌患者和健康受试者的 QoL。使用倾向评分匹配将甲状腺癌幸存者与健康受试者（1:5 匹配）进行匹配。
单变量分析的线性回归显示，患有甲状腺癌与 EQ-5D 指数评分的提高呈正相关（β系数=0.010，p=0.046）。在调整了多个协变量后，这种相关性仍然具有统计学意义。EQ-VAS 未能显示出任何显著相关性。在 EQ-5D 类别中，甲状腺癌患者的自我护理能力好于健康受试者。甲状腺癌的持续时间与 EQ-5D 指数评分无关。在亚组分析中，与甲状腺癌持续时间<5 年的患者相比，甲状腺癌持续时间为 5-9 年和≥10 年的患者，其 EQ-5D 指数评分与生存时间之间的相关性无显著差异。
使用大规模的全国性基于人群的数据库，我们的研究表明，与没有癌症的健康受试者相比，甲状腺癌幸存者的 QoL 更好，特别是在自我护理方面。
